Calcium phosphate bone cements for local therapy of defects of the systemically diseased bone ((02) M02)

用于局部治疗全身病变骨缺损的磷酸钙骨水泥 ((02) M02)

• 批准号: 170580341
• 金额: --
• 依托单位: Zentrum für Translationale Knochen-, Gelenk- und Weichgewebeforschung
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/170580341?language=en
• 关键词: Calcium; phosphate; bone; cements; local

In M2, an application system for pasty calcium phosphate cements (CPC) allowing extrusion of CPC in combination with a drug-loaded aqueous phase (hydrogel, solution or suspension) as core/shell structure is to be developed and characterized regarding drug release. The composites consisting of CPC and mesoporous bioactive glass or xerogels (M3) will be further developed and characterized with respect to their application as drug carrier. In addition, strategies for usage of the CPC as carrier for therapeutic antibodies are intended to develop and evaluate. In cooperation with B1 and B13, 3D models for in vitro simulation of osteolyses will be generated.

在 M2 中，将开发一种糊状磷酸钙水泥 (CPC) 的应用系统，该系统允许将 CPC 与载药水相（水凝胶、溶液或悬浮液）组合挤出作为核/壳结构，并对其药物释放进行表征。由CPC和介孔生物活性玻璃或干凝胶（M3）组成的复合材料将在其作为药物载体的应用方面得到进一步开发和表征。此外，还打算开发和评估使用 CPC 作为治疗性抗体载体的策略。与 B1 和 B13 合作，将生成用于体外模拟溶骨的 3D 模型。