Engineering cartilage homeostasis in health and disease

工程软骨稳态在健康和疾病中的应用

• 批准号: DP0988001
• 负责人: Prof David Smith
• 金额: $ 15.94万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988001
• 关键词: Engineering; cartilage; homeostasis; health; disease

Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mechanisms of cartilage degradation. New experiments will be used to validate the model and test predictions. The model developed will provide fundamental insights into what is required for the maintenance of healthy cartilage, and what happens in injury-induced degradation of cartilage.

关节炎是一种常见的、痛苦的、经常使人虚弱的疾病，影响着16%的澳大利亚人口，每年给这个社区造成110亿美元的损失。目前尚不清楚软骨退化为关节疾病的原因，也不清楚它如何逆转--部分原因是涉及大量的机制。这个项目旨在通过开发一个可以整合软骨降解的各种机制的软骨计算模型来克服这种复杂性。新的实验将被用来验证模型和测试预测。开发的模型将提供对维持健康软骨所需的基本见解，以及在损伤诱导的软骨退化中发生的情况。