The comparative physiology of oxygen delivery to the kidney

肾脏有高氧的危险，因为相对于它的体积，肾脏接受了太多的血液。有人提出，在动脉和静脉之间分流氧气可以大大降低高氧的风险，但在某些情况下，分流会大大增加肾脏缺氧的风险。利用同步加速器和组织学成像的结合，本项目将仔细定义几种不同物种肾皮质的三维血管系统，并使用计算模型解释其功能意义。该项目的结果将是对肾脏中氧运输和分流的比较生理学的新认识。

The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of the renal cortex in several different species and interpret its functional significance using computational modeling. The outcome of this project will be a new understanding in the comparative physiology of oxygen transport and shunting in the kidney.