Fundamental theoretical and experimental investigation of cartilage mechanics

软骨力学的基础理论与实验研究

• 批准号: DP0450786
• 负责人: Prof David Smith
• 金额: $ 19.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-05-21 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450786
• 关键词: Fundamental; theoretical; experimental; investigation; cartilage

Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.

关节炎和慢性关节症状是社区残疾的主要原因之一，但对关节力学的基本理解尚未实现。该项目的目的是开发一种新的最先进的数学模型，描述人类软骨行为。该模型将解释步行等活动如何通过组织转移生长因子来保持健康的软骨，并定量解释如何通过渗出润滑来最大限度地减少软骨磨损。这个模型将促进我们对健康和疾病中软骨力学的理解，从而帮助澳大利亚人健康和富有成效地衰老。