2005 Epigenetics Gordon Research Conference Held at Holderness School, New Hampshire on August 7-12, 2005.

项目摘要，2005年表观遗传学戈登研究会议表观遗传学的研究涉及到基因产生表型的极其复杂的机制。它涉及到几乎所有生物体发育的方方面面，并很好地提醒人们，毕竟，基因型如何产生表型的本质并不完全存在于DNA中。该提案请求支持将于2005年8月7日至12日在新罕布夏州霍尔德内斯学校举行的第六届戈登表观遗传学研究会议。受邀的演讲者是从事原核生物、真菌、纤毛虫、植物、蠕虫、昆虫和哺乳动物的主要研究人员，他们的演讲将涵盖当今最引人入胜的科学领域，包括分子和细胞记忆、细胞去分化、DNA不对称、DNA甲基化、RNA干扰、亲本印记、X染色体失活、顺变、倍性、开关、环境压力、基因组防御系统、位置效应、组蛋白修饰、哺乳动物克隆和干细胞发展。特别令人感兴趣的是新发现的现象，其潜在的机制目前是神秘的。2005年戈登表观遗传学研究会议将为致力于这一广泛机制和有机体的研究人员提供一个独特的环境，让他们齐聚一堂，交流结果和想法。由于报名人数有限，正式和非正式讨论的时间充裕，本次会议的跨学科环境将培养创新思维和新颖的合作，这对表观遗传学领域的研究人员的成功至关重要。最后，2005年会议将一如既往地高度重视促进青年研究人员的科学和事业，并增加科学界的多样性。

Project Summary, 2005 Epigenetics Gordon Research Conference The study of epigenetics concerns the enormously complex mechanisms by which genotype gives rise to phenotype. It pertains to every aspect of development in virtually all organisms and has been a good reminder that the essence of how genotype gives rise to phenotype does not, after all, reside completely in DNA. This proposal requests support for the sixth Gordon Research Conference on Epigenetics to be held at Holderness School, New Hampshire, August 7-12, 2005. Invited speakers are leading researchers working on prokaryotes, fungi, ciliates, plants, worms, insects, and mammals, and their presentations will cover some of the most fascinating areas of science today, including molecular and cellular memory, cellular de-differentiation, DNA asymmetry, DNA methylation, RNA interference, parental imprinting, X-chromosome inactivation, paramutation, ploidy, switching, environmental stress, genome defense systems, position effects, histone modifications, mammalian cloning, and stem cell development. Of particular interest are newly-recognized phenomena whose underlying mechanisms are currently mysterious. The 2005 Gordon Research Conference on Epigenetics will provide a unique setting for researchers working on this broad spectrum of mechanisms and organisms to come together and exchange results and ideas. With a limited enrollment and ample time for formal and informal discussions, the cross-disciplinary environment of this conference will foster the innovative thinking and novel collaborations that are critical for the success of researchers in the field of epigenetics. Finally, as has always been the case with this series, the 2005 Conference will place a high priority on promoting the science and careers of young investigators and increasing the diversity of the scientific community.