SGER: Novel Antifungal Materials and Surfaces

SGER：新型抗真菌材料和表面

• 批准号: 0507449
• 负责人: Robert Langer
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0507449&HistoricalAwards=false
• 关键词: SGER; Novel; Antifungal; Materials; Surfaces

0507449LangerThis proposed research delineates a number of novel approaches for grafting antifungal molecules to polymeric surfaces or incorporating those compounds within the polymeric matrix. The chemistry is challenging, as inappropriate modifications may abolish the fungicidal activity of the molecules, and their specific chemical properties make them hard to work with. The methodologies developed here will be applicable not only to the set of chemistries described here, but to surface modification in general. The potential uses are also broad, ranging from the prevention of fouling of industrial fermenters, sewage systems, and shipping hulls, to preventing fungal infections of catheters. The project follows a systematic approach whereby molecules are synthesized to predetermined specifications, tested in vitro against C. albicans, and then - if shown to be effective - tested in animals for efficacy and safety.

0507449 Langer这项研究提出了一些新的方法，用于将抗真菌分子接枝到聚合物表面或将这些化合物掺入聚合物基质中。化学是具有挑战性的，因为不适当的修饰可能会消除分子的杀真菌活性，并且它们的特定化学性质使它们难以使用。这里开发的方法将不仅适用于这里描述的一组化学，但一般的表面改性。潜在的用途也很广泛，从防止工业发酵罐、污水系统和船体的污染，到防止导管的真菌感染。该项目遵循一种系统的方法，即分子合成到预定的规格，在体外测试对C。白色念珠菌，然后-如果显示有效-在动物中测试功效和安全性。