Diffusive Transport in Porous Polymers

多孔聚合物中的扩散传输

• 批准号: 8611637
• 负责人: Robert Langer
• 金额: $ 5万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8611637&HistoricalAwards=false
• 关键词: Diffusive; Transport; Porous; Polymers

The controlled release of macromolecules from a porous polymer carrier is an example of diffusion through a porous medium; a complete understanding of the behavior of these systems in not available. A microstructural approach to the problem will be taken with the goal of elucidating the underlying physical mechanisms which determine the rate of transport in the porous network. The research involves a system for acquiring detailed microstructural data on the porous polymer devices. A detailed understanding permits the formulation of physically realistic models of the porous network; it will also provide a method for testing preliminary hypotheses. Release studies are also conducted for examining the kinetics of macromolecular release from the polymer devices. The major thrust of the project is exploratory experimentation on the physical mechanisms.

大分子从多孔聚合物载体的受控释放是在多孔介质中扩散的一个例子；完全了解这些系统的行为是不可能的。将采取微观结构的方法来解决这个问题，目的是阐明决定多孔网络中传输速度的基本物理机制。这项研究涉及一个系统，用于获取关于多孔聚合物器件的详细微结构数据。通过详细的理解，可以制定出物理上真实的多孔网络模型；它还将提供一种检验初步假设的方法。还进行了释放研究，以考察从聚合物装置中释放大分子的动力学。该项目的主要目的是对物理机制进行探索性实验。