SBIR Phase I: Nanobiosensor for Cancer Marker Detection

SBIR 第一阶段：用于癌症标志物检测的纳米生物传感器

• 批准号: 0510256
• 负责人: Youssef Habib
• 金额: $ 10万
• 依托单位: ILLUMINEX CORP
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0510256&HistoricalAwards=false
• 关键词: SBIR; Phase; Nanobiosensor; Cancer; Marker

This Small Business Innovation Research Phase I project seeks to develop a nanobiosensor for optically detecting, discriminating, and quantifying important bio-molecular species. This project focuses on detection of ovarian cancer markers. The sensor technology is based on manufacturing arrays of silver nanowires on optical substrates and then bio-chemically functionalizing the nanowires to bind specific biological analytes. The presence of the targeted analyte is determined using the ultra-sensitive optical-probing technique, Surface Enhanced Raman Scattering (SERS). This project will seek to utilize novel manufacturing techniques to build a versatile bio-sensing platform that can be readily altered to sense a wide range of important biological species. The Phase I project will engineer the nanobiosensor to detect the presence of the cancer marker CA125. The detection and diagnosis of disease is one of the major potential applications of nanotechnology, which allows devices to be manufactured on the same size scale as the biological species and chemicals they seek to detect. Phase II work will expand the range of cancer marker detection and incorporate the sensing platform into a portable, easy to use medical diagnostic tool. This innovative technology will find applications in medical testing, environmental monitoring, and chemical and biological weapons detection.

这个小型企业创新研究第一阶段项目旨在开发一种纳米生物传感器，用于光学检测、区分和量化重要的生物分子物种。本项目主要研究卵巢癌标志物的检测。该传感器技术基于在光学衬底上制造银纳米线阵列，然后对纳米线进行生化功能化以结合特定的生物分析物。目标分析物的存在是使用超灵敏的光学探测技术，表面增强拉曼散射（SERS）来确定的。该项目将寻求利用新颖的制造技术来建立一个多功能的生物传感平台，该平台可以很容易地改变以传感广泛的重要生物物种。第一阶段项目将设计纳米生物传感器来检测癌症标志物CA125的存在。疾病的检测和诊断是纳米技术的主要潜在应用之一，它允许以与它们寻求检测的生物物种和化学物质相同的规模制造设备。二期工作将扩大癌症标志物检测的范围，并将传感平台纳入便携式，易于使用的医疗诊断工具。这项创新技术将应用于医学测试、环境监测以及化学和生物武器检测。