SBIR Phase I: Functionalized Nanowire Chem/Bio SERS Optical Detectors

这个小企业创新研究第一阶段项目旨在开发一种新型的生物和化学试剂检测系统，该系统利用纳米线中的光学共振在分子和亚分子水平上探测致病物种。该项目将研究使用功能化金纳米线基底进行表面增强拉曼散射（Sers）分析来检测农药。高纵横比纳米线阵列将被设计和功能化以检测目标分子。该项目将联合收割机免疫分析，拉曼光谱和纳米工程技术，目标是开发具有前所未有的灵敏度的检测器。Sers是一种众所周知的非常精确的检测方法，可用于鉴定单分子、抗原、核酸序列和蛋白质结构。该项目的目标是开发增强型纳米线Sers基底，用于集成到具有二极管泵浦激光器和电荷耦合器件传感器的多通道光纤纳米线异质结构光学检测器中，以制造坚固，紧凑，便携，高精度，和现场可用的生物或化学制剂传感器。该项目的商业应用将在低浓度的使环境中的致病性化学或生物制剂达到一定水平。它将用于环境监测、医学测试和监测生物武器的释放。该装置被设计成通过其独特的拉曼特征来识别几乎任何分子或细胞物种。

This Small Business Innovation Research Phase I project seeks to develop a novel biological and chemical agent detection system that utilizes optical resonances in nanowires to probe pathogenic species on the molecular and submolecular levels. The project will study the detection of pesticides using functionalized gold nanowire substrates for surface enhanced Raman scattering (SERS) analysis. Arrays of high-aspect ratio nanowires will be engineered and functionalized to detect a target molecule. The project will combine the techniques of immunoassay, Raman spectroscopy, and nanoengineering, with the goal of developing a detector with unprecedented sensitivity. SERS is well a known and extremely accurate detection method that can be employed to identify single molecules, antigens, nucleic acid sequences and protein structure. The goal of the project is to develop enhanced nanowire SERS substrates for integration into a multiple channel fiber-optic nanowire heterostructure optical detector with diode pumped lasers and a charge coupled device sensor to make a rugged, compact, portable, highly accurate, and field -ready biological or chemical agent sensor.The commercial application of this project will be in the detection of low-level quantities of pathogenic chemical or biological agents in the environment. It will be used environmental monitoring, medical testing, and monitoring for release of biological weapons. The device is being designed to identify virtually any molecular or cellular species by its unique Raman signature.