Chromatography Opportunities for Learning and Understanding of Modern Separations (COLUMNS)

学习和理解现代分离的色谱机会 (COLUMNS)

• 批准号: 0511390
• 负责人: Marcus McEllistrem
• 金额: $ 10万
• 依托单位: University of Wisconsin-Eau Claire
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0511390&HistoricalAwards=false
• 关键词: Chromatography; Opportunities; Learning; Understanding; Modern

Chemistry (12) Chromatography is a key method in nearly every subdiscipline of chemistry and in interdisciplinary fields such as pharmaceuticals, forensics, and environmental science. This project is providing students with exposure to and training in the most common separation method, High Performance Liquid Chromatography (HPLC). A vertically integrated laboratory curriculum in chromatography is instilling a deep understanding of modern separation science in chemistry and biology students. This coordinated education program is being implemented in five courses: general chemistry, quantitative and instrumental analysis, and two biochemistry labs. These courses span the chemistry and biochemistry major curricula. The project is adapting literature-based experiments in HPLC, mostly from the Journal of Chemical Education, in order to create a coherent program that requires students in the advanced courses to apply their understanding of chromatographic principles learned in the introductory courses. The intellectual and pedagogic merit of the proposed curriculum is that it offers students HPLC experience in two introductory courses: general chemistry and quantitative analysis, and in two advanced chemistry courses: instrumental analysis and biochemistry. Given the structure of the chemistry and biochemistry curricula at the institution, students thus have chromatography experiences in three courses. In the two introductory courses, students in general chemistry explore molecular polarity and examine how it directly influences a modern instrumental analysis, and students in quantitative analysis examine the chromatographic theory applicable to HPLC and carry out student-designed final projects based on analytical procedures from the literature. In the advanced chemistry courses, students in biochemistry use HPLC to purify and characterize a small peptide (first semester lab) and in student-designed projects (second semester lab), and students in instrumental analysis use HPLC in the analysis of capsaicinoids and in student-designed projects that serve as a culminating experience. Of the four courses that are incorporating new HPLC experiences, three either include a final project wholly driven by the student or are completely project-oriented. The broader impacts of this project include providing a cross-curriculum educational program, which is enabling students to learn how separation methods work and also to make connections between different courses and subdisciplines within their major field, producing stronger ties between courses; incorporating modern separation methods and theory into the chemistry curriculum; using modern instruments in student-centered, student-driven projects; implementing a multi-course assessment plan that provides feedback for continued improvement of the teaching and learning in the program, and which is providing new and unique learning experiences for student collaborators involved in the evaluation; fostering collaborations between chemistry and biology faculty in order to provide biology students with strong experiences in chromatography; creating a new environment in which chemists and biologists are collaborating, in both teaching and research; and providing new facilities that are of value in diverse faculty/student research programs.

化学（12） 色谱法是化学的几乎每个分支学科和跨学科领域（如制药，法医学和环境科学）的关键方法。该项目为学生提供最常见的分离方法，高效液相色谱法（HPLC）的接触和培训。 在色谱垂直整合实验室课程正在灌输化学和生物学学生对现代分离科学的深刻理解。 这个协调的教育计划正在实施五门课程：普通化学，定量和仪器分析，以及两个生物化学实验室。这些课程跨越化学和生物化学专业课程。该项目正在改编基于文献的HPLC实验，主要来自《化学教育杂志》，以创建一个连贯的程序，要求高级课程的学生应用他们在入门课程中所学的色谱原理。 拟议的课程的智力和教学价值是，它为学生提供HPLC经验，在两个入门课程：普通化学和定量分析，并在两个先进的化学课程：仪器分析和生物化学。鉴于该机构的化学和生物化学课程的结构，学生因此在三门课程中拥有色谱经验。在这两门入门课程中，普通化学专业的学生探索分子极性，并研究它如何直接影响现代仪器分析，定量分析专业的学生研究适用于HPLC的色谱理论，并根据文献中的分析程序进行学生设计的最终项目。在高级化学课程中，生物化学专业的学生使用HPLC纯化和表征小肽（第一学期实验室）和学生设计的项目（第二学期实验室），仪器分析专业的学生使用HPLC分析辣椒素和学生设计的项目，作为最终的经验。在四门课程中，有三门课程包含了一个完全由学生驱动的最终项目，或者完全以项目为导向。 该项目的更广泛的影响包括提供一个跨课程的教育方案，使学生能够学习分离方法如何工作，并在其主要领域内的不同课程和分支学科之间建立联系，在课程之间建立更强的联系;将现代分离方法和理论纳入化学课程;在以学生为中心、学生驱动的项目中使用现代仪器;实施多课程评估计划，为持续改进该计划中的教学提供反馈，并为参与评估的学生合作者提供新的独特的学习体验;促进化学和生物学教师之间的合作，为生物学学生提供色谱方面的丰富经验;创造一个化学家和生物学家在教学和研究方面合作的新环境;并提供在不同的教师/学生研究计划中具有价值的新设施。