Investigating the activator function of the Bim protein

研究 Bim 蛋白的激活剂功能

• 批准号: DP0988643
• 负责人: Dr Delphine Merino
• 金额: $ 16.35万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988643
• 关键词: Investigating; activator; function; Bim; protein

Apoptosis is a research area where Australia has had long standing success. The first observations of this important process were made by Prof John Kerr in the 60's and 70's. A molecular renaissance developed in the late 80's and has led to the current explosion in this area of research. Many of these recent studies have been conducted at the Walter and Eliza Hall Institute. Our scientific endeavour is aimed at broadening the understanding of the mechanisms of cell death using genetically modified mouse models. Insights gained through this project will have far reaching implications for the design of new drugs to combat cancer and degenerative diseases.

细胞凋亡是澳大利亚长期以来取得成功的一个研究领域。这一重要过程的第一次观察是由约翰·克尔教授在60年代和70年代提出的。80年代后期发展起来的分子复兴导致了这一研究领域的爆炸式发展。最近的许多研究都是在沃尔特和伊丽莎霍尔研究所进行的。我们的科学努力旨在利用转基因小鼠模型扩大对细胞死亡机制的理解。通过该项目获得的见解将对设计对抗癌症和退行性疾病的新药产生深远的影响。