Collaborative Research: Role of Neuronal Activity in Visually Guided Escape Behaviors
合作研究:神经元活动在视觉引导逃生行为中的作用
基本信息
- 批准号:0516775
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-01 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Avoidance of collisions is critical to survival and the activity of sensory and motor neurons thought to be involved in visually-guided escape has been studied in several species. However, the mechanisms by which visual information processed in sensory areas leads to the preparation and execution of escape remains poorly understood. The current project addresses this question by studying escape of freely behaving locusts in response to simulated objects approaching on a collision course and by coupling these studies with electrophysiological recordings of neuronal activity both in restrained and freely moving animals. The locust will be studied because the neural pathways involved in generating escape behavior are well characterized and are accessible for neurophysiological investigation. The project will use a multi-disciplinary approach, combining behavior, neurophysiology and computer engineering to relate the generation of escape behaviors to the coding of visual stimuli in the activity of individual nerve cells. Gabbiani and his collaborators will first characterize how the timing of various stages of escape jumps elicited in locusts by the approach of an object on a collision course depends on the speed and size of the approaching object. Animals will be filmed with a high speed-video system as they jump from the simulated approach of objects, or looming stimuli. Next, in restrained animals, the electrical activity of neurons sensitive to looming, which relay information from sensory to motor centers in the locust central nervous system, will be examined in response to similar stimulus conditions. One individual neuron thought to be critical in this process, the descending contralateral motion detector (DCMD) neuron, will be studied in detail. In parallel to these neurophysiological studies, computer engineers on the project will develop a miniature digital wireless recording and transmission system able to be carried by the locust. This system will transmit up to eight channels of neuronal data from electrodes implanted in the insect's nervous system, including signals from the DCMD cell studied in the restrained locust. The small device will affixed to the back of locusts to monitor nervous activity in real time during escape jumps. In separate experiments, the muscular activity leading to the generation of jumps will be monitored as well. Taken together, this study will for the first time investigate quantitatively the relation between stimulus parameters, the activity of sensory neurons and the motor stages of a visually guided escape behavior in freely behaving animals, thus leading to an integrated understanding of the connection between its sensory and motor components. This project also has a broader imact beyond the research community. Dr. Gabbiani has worked, and will continue to work, closely with a high school science teacher in his laboratory to develop high school science curriculum modules on the neural control of behavior and the integration of computer engineering with biology. The project will also support the interdisciplinary training of several graduate students.
避免碰撞对生存至关重要,已经研究了一些物种的感觉和运动神经元的活动,这些神经元被认为与视觉引导的逃跑有关。然而,感官区域处理的视觉信息导致逃跑的准备和执行的机制仍然知之甚少。目前的项目通过研究自由行为的蝗虫对碰撞过程中接近的模拟物体的逃跑反应,并将这些研究与受限制和自由移动的动物的神经元活动的电生理记录相结合,来解决这个问题。蝗虫之所以会被研究,是因为产生逃跑行为的神经通路已经很好地描述了,并且可以进行神经生理学研究。该项目将采用多学科方法,结合行为学、神经生理学和计算机工程,将逃逸行为的产生与单个神经细胞活动中视觉刺激的编码联系起来。Gabbiani和他的合作者将首先描述在碰撞过程中,当物体接近时,蝗虫的逃脱跳跃的各个阶段的时间如何取决于接近物体的速度和大小。当动物从模拟的接近物体或隐现的刺激物中跳跃时,将被高速视频系统拍摄下来。接下来,在受限制的动物中,对若隐若现敏感的神经元的电活动(将信息从蝗虫中枢神经系统的感觉中心传递到运动中心)将被检查对类似刺激条件的反应。一个被认为在这个过程中至关重要的单个神经元,下行对侧运动检测器(DCMD)神经元,将被详细研究。在进行这些神经生理学研究的同时,参与该项目的计算机工程师将开发一种能够由蝗虫携带的微型数字无线记录和传输系统。该系统将传输多达8个通道的神经元数据,这些数据来自植入昆虫神经系统的电极,包括在受限蝗虫中研究的DCMD细胞的信号。这个小装置将被固定在蝗虫的背部,以实时监测它们在逃跑跳跃过程中的神经活动。在单独的实验中,导致跳跃产生的肌肉活动也将被监测。综上所述,本研究将首次定量研究自由行为动物视觉引导逃跑行为的刺激参数、感觉神经元活动和运动阶段之间的关系,从而对其感觉和运动成分之间的联系有一个全面的了解。这个项目也有更广泛的影响,超出了研究界。Gabbiani博士已经并将继续在他的实验室里与一位高中科学老师密切合作,开发有关行为的神经控制以及计算机工程与生物学的整合的高中科学课程模块。该项目还将支持多名研究生的跨学科培训。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fabrizio Gabbiani其他文献
A switch for oscillatory bursting
用于振荡爆发的开关
- DOI:
10.1038/nn0303-212 - 发表时间:
2003-03-01 - 期刊:
- 影响因子:20.000
- 作者:
Fabrizio Gabbiani - 通讯作者:
Fabrizio Gabbiani
Lifetime difference in <math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll" class="math"><msub><mi>B</mi><mi>s</mi></msub></math> mixing: Standard Model and beyond
- DOI:
10.1016/j.physletb.2007.07.049 - 发表时间:
2007-09-20 - 期刊:
- 影响因子:
- 作者:
Andriy Badin;Fabrizio Gabbiani;Alexey A. Petrov - 通讯作者:
Alexey A. Petrov
Fabrizio Gabbiani的其他文献
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{{ truncateString('Fabrizio Gabbiani', 18)}}的其他基金
Elucidating the Role of ON and OFF Visual Pathways in Object Segmentation for Escape Behavior
阐明 ON 和 OFF 视觉通路在逃逸行为对象分割中的作用
- 批准号:
2212750 - 财政年份:2023
- 资助金额:
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Standard Grant
BII-Implementation: Behavioral Plasticity Research Institute (BPRI): Transforming the Study of Phenotypic Plasticity through Biological Integration
BII-实施:行为可塑性研究所 (BPRI):通过生物整合转变表型可塑性的研究
- 批准号:
2021795 - 财政年份:2020
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Cooperative Agreement
CRCNS: Functional Dissection of a Looming-Sensitive Neural Pathway in Drosophila
CRCNS:果蝇中隐现敏感神经通路的功能解剖
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1607518 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Continuing Grant
Collaborative Research: Dendritic Processing of Topographic Information in a Collision Detecting Neuron
合作研究:碰撞检测神经元中地形信息的树突状处理
- 批准号:
1120952 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Integrated Analysis of In-Flight Collision Avoidance Systems
合作研究:飞行中防撞系统的综合分析
- 批准号:
0904065 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Standard Grant
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