Synthesis and Evaluation of Pyrrole-Modified Porphyrins

吡咯修饰卟啉的合成与评价

• 批准号: 0517782
• 负责人: Christian Brueckner
• 金额: --
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0517782&HistoricalAwards=false
• 关键词: Synthesis; Evaluation; Pyrrole; Modified; Porphyrins

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Christian Bruckner of the Department of Chemistry at the University of Connecticut. The research project centers on the synthesis and evaluation of pyrrole-modified porphyrins. Pyrrole-modified porphyrins are macrocycles derived from porphyrins by formally replacing at least one pyrrolic building block with a different heterocyclic ring. The guiding hypothesis of the work is that these modifications will result in molecules with drastically altered electronic properties as compared to porphyrins, particularly with respect to their photophysical properties such as ultra violet-visible and two photon absorbance, emission, and resonance Raman spectra. The photophysical properties of the newly synthesized porphyrins will be correlated with their structural parameters such as the degree of non-planarity and conformational flexibility. An understanding of these relationships will allow the synthesis of porphyrins with designed photophysical properties.This project, which will result in expansion of the synthetic methodologies used in the porphyrin field, will facilitate the synthesis of a variety of novel materials. These substances, with their unique photophysical properties, are likely to have application as sensors and in the biomedical field as photo-therapeutics and photodiagnostic imaging agents. The program involves multidisciplinary training for undergraduate and graduate students in organic synthesis, coordination chemistry, and spectroscopic structure determination. Year-round undergraduate research projects will be part of this project. The research will be facilitated by international collaborations in Germany and Great Britain and by a collaboration with a local undergraduate institution.

有了这个新的奖项，有机和高分子化学项目支持了康涅狄格大学化学系克里斯蒂安·布鲁克纳教授的工作。本研究项目以吡咯修饰的卟啉化合物的合成和评价为中心。吡咯修饰的卟啉是通过用不同的杂环形式取代至少一个吡咯构筑块而从卟啉衍生的大环。这项工作的指导假设是，与卟啉相比，这些修饰将导致分子的电子性质发生巨大变化，特别是在其光物理性质方面，如紫外线-可见和双光子吸收、发射和共振拉曼光谱。新合成的卟啉的光物理性质将与其非平面度、构象柔性等结构参数相关联。对这些关系的理解将有助于合成具有设计的光物理性质的卟啉。该项目将导致扩大用于卟啉领域的合成方法，将促进各种新材料的合成。这些物质由于其独特的光物理性质，很可能作为传感器和作为光疗法和光诊断成像剂在生物医学领域中应用。该计划包括对本科生和研究生进行有机合成、配位化学和光谱结构测定的多学科培训。全年的本科生研究项目将是该项目的一部分。这项研究将通过德国和英国的国际合作以及与当地本科生机构的合作来促进。