MRI: Track 1 Acquisition of a 400 MHz NMR Spectrometer to Expand and Secure Solution NMR Spectroscopy at UConn with Facility Helium Stewardship

MRI：轨道 1 采购 400 MHz NMR 波谱仪，通过设施氦气管理来扩展和保护康涅狄格大学的 NMR 波谱解决方案

• 批准号: 2320586
• 负责人: Christian Brueckner
• 金额: $ 79.89万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320586&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; 400; MHz

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. University of Connecticut is acquiring a 400 MHz NMR spectrometer equipped with a broadband three-channel probe to support the research of Professor Christian Brueckner and colleague Mark Peczuh. In response to the solicitation for proposals to contribute to the recovery, recycle, and/or reuse of helium initiated by the CHIPS and Science Act of 2022, this award also includes a helium recovery system. This award facilitates research in the areas of nanoscale materials characterization, organic and inorganic chemistry, and biological sciences. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The superconducting magnets of these instruments rely on regular deliveries of liquid helium to maintain their operation. However, the instability in the helium supply due to global and national challenges jeopardizes research programs relying on NMR spectroscopy. The helium recovery system collects the helium boiloff from the superconducting magnets and then reliquefies the helium for reuse. This award targets the enhancement of educational, research, and research training at all levels in multiple departments including several early career faculty and undergraduate and graduate students and in the surrounding community. This instrument is also used to propel the NMR-themed outreach program for local high school teachers and students.This award is aimed at enhancing research and education at all levels, especially in areas such as chemistry, pharmacy, molecular and cellular biology, and engineering. Specifically, the instrument enables research focusing on the synthesis of small molecules exhibiting circularly polarized luminescence and the computational and experimental design of associating bottle brush mesostructures. Additional research projects to be enabled by the 400 MHz NMR spectrometer include the design and synthesize of new functional biomaterials, including modified natural polymers, such as Bombyx mori silk protein. Other research activities include the synthesis and photochemical characterization of azobenzene photoswitches; the systematic design, analysis and control of manufacturable nano-machines; and the examination of surface ligands and surface chemistry of metal nanoparticles. Other investigations include understanding how various cellular signaling pathways contribute to tumor onset and progression, and analyzing the design and synthesize of nucleic acid nanomaterials for a variety of medical applications. In response to global helium supply challenges the helium recovery system aids in helium conservation by recovering, recycling, and reliquefying the helium boil-off from this instrument and the existing NMR superconducting magnets at the institution.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器（MRI）和化学研究仪器（CRIF）计划共同支持。康涅狄格大学正在购买一台配备宽带三通道探头的400 MHz NMR光谱仪，以支持Christian Brueckner教授和同事Mark Peczuh的研究。为了响应2022年CHIPS和科学法案发起的回收，再循环和/或再利用氦气的提案征集，该奖项还包括氦气回收系统。该奖项促进了纳米材料表征、有机和无机化学以及生物科学领域的研究。 一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。利用原子核的固有磁性，它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些仪器的超导磁体依赖于定期输送的液氦来维持其运行。然而，由于全球和国家的挑战，氦供应的不稳定性危及依赖NMR光谱的研究计划。氦回收系统收集来自超导磁体的氦蒸发，然后将氦重新蒸发以供再利用。该奖项的目标是在多个部门，包括几个早期职业教师和本科生和研究生以及周围社区的各级教育，研究和研究培训的增强。该奖项旨在加强各级的研究和教育，特别是在化学、药学、分子和细胞生物学以及工程等领域。具体而言，该仪器使研究重点放在表现出圆偏振发光的小分子的合成和关联瓶刷介观结构的计算和实验设计。400 MHz核磁共振波谱仪还将支持其他研究项目，包括设计和合成新的功能性生物材料，包括改性天然聚合物，如桑蚕丝蛋白。其他研究活动包括偶氮苯光开关的合成和光化学表征;可制造纳米机器的系统设计，分析和控制;以及金属纳米颗粒的表面配体和表面化学的检查。其他研究包括了解各种细胞信号传导途径如何促进肿瘤的发生和发展，并分析用于各种医疗应用的核酸纳米材料的设计和合成。为了应对全球氦供应的挑战，氦回收系统通过回收、再循环和再利用从该仪器和该机构现有的NMR超导磁体中蒸发的氦来帮助保存氦。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。