Synthesis and Evaluation of Pyrrole-Modified Porphyrins

吡咯修饰卟啉的合成与评价

• 批准号: 1058846
• 负责人: Christian Brueckner
• 金额: $ 40.5万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058846&HistoricalAwards=false
• 关键词: Synthesis; Evaluation; Pyrrole; Modified; Porphyrins

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Christian Brueckner of the University of Connecticut, for the synthesis of pyrrole-modified porphyrins from meso-tetraarylporphyrins and the determination of structure/property relationships for this important class of organic molecule. The goal of this work is to establish connections between structural changes in one of the pyrrole sub-units of the porphyrin ring (degree of saturation, steric bulk, and conformational flexibility) and the observed electronic properties in both the ground and electronically excited states (absorption and emission wavelengths, excited state lifetimes). Structurally modified porphyrins find wide applicability in many technical fields, such as therapeutics for disease treatment, chemosensors, and biological imaging agents.Broader impacts of the research include the multidisciplinary training opportunities for students, from organic synthesis to photochemistry and photophysics. Potential applications for the synthesized molecules include photodynamic therapy agents for cancer treatment, photoacoustic imaging contrast enhancement, and monitoring the aging process in concrete. These applications will be assessed through Professor Brueckner's collaborations with researchers in the biomedical and engineering fields; this includes an international collaboration in the UK. Undergraduate participation in this research will be year-round through an established REU program at the Univeristy of Connecticut, and there is also significant involvement with a local undergraduate institution (Central Connecticut State University).

美国国家科学基金会化学部的化学结构，动力学和机制计划支持康涅狄格大学的Christian Brueckner教授从meso-tetraarylporphyrins合成吡咯修饰的卟啉，并确定这类重要的有机分子的结构/性质关系。 这项工作的目标是建立卟啉环的一个吡咯亚单元的结构变化（饱和度、空间体积和构象灵活性）与基态和电子激发态中观察到的电子性质（吸收和发射）之间的联系。波长、激发态寿命）。结构修饰的卟啉在许多技术领域有着广泛的应用，如疾病治疗、化学传感器和生物成像剂。更广泛的影响包括为学生提供从有机合成到光化学和光物理的多学科培训机会。 合成分子的潜在应用包括用于癌症治疗的光动力治疗剂、光声成像对比度增强和监测混凝土中的老化过程。 这些应用将通过Brueckner教授与生物医学和工程领域研究人员的合作进行评估;这包括在英国的国际合作。 本科生参与这项研究将是全年通过一个既定的REU计划在康涅狄格大学，也有显着参与当地的本科院校（中央康涅狄格州立大学）。