ME: Engineering E. coli to Maximize the Flux of Reducing Equivalents Available for NAD(P)H-Dependent Transformations
ME:工程大肠杆菌以最大化可用于 NAD(P)H 依赖性转化的还原当量通量
基本信息
- 批准号:0519516
- 负责人:
- 金额:$ 63.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-12-15 至 2009-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cirino0519516This research is to resolve issues regarding enzymatic transformations catalyzed by reduced nicotinamide cofactor dependent reductases, dehydrogenases, and oxygenases. It is proposed to metabolically engineer E. coli strains such that sugars will be completely oxidized without fermentation end products and the resulting reducing equivalents diverted away from aerobic respiration toward driving other reactions of interest. A broader impact of the research is the development of viable routes to renewable fuels and chemicals by optimizing the efficiency with which biomass is utilized for medically and industrially significant biotransformations. Computational modeling will guide design efforts and experimental results will serve to correct and complete the modeling frameworks.
Cirino0519516本研究旨在解决由还原的烟酰胺辅因子依赖还原酶、脱氢酶和加氧酶催化的酶转化问题。有人建议对大肠杆菌菌株进行新陈代谢改造,使糖在没有发酵最终产物的情况下完全氧化,由此产生的还原当量从有氧呼吸转向驱动其他感兴趣的反应。这项研究的一个更广泛的影响是,通过优化生物质用于医学和工业上重大生物转化的效率,开发了获得可再生燃料和化学品的可行途径。计算建模将指导设计工作,实验结果将用于纠正和完善建模框架。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Patrick Cirino其他文献
Patrick Cirino的其他文献
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{{ truncateString('Patrick Cirino', 18)}}的其他基金
SusChEM: Collaborative Research: Efficient biological activation and conversion of short-chain hydrocarbons
SusChEM:合作研究:短链碳氢化合物的高效生物活化和转化
- 批准号:
1705888 - 财政年份:2017
- 资助金额:
$ 63.57万 - 项目类别:
Standard Grant
UNS: Combining strain recombineering with molecular reporters and customized selections to overcome limitations in producing renewable hydrocarbons
UNS:将菌株重组与分子报告基因和定制选择相结合,以克服生产可再生碳氢化合物的限制
- 批准号:
1511425 - 财政年份:2015
- 资助金额:
$ 63.57万 - 项目类别:
Standard Grant
Collaborative Research: Metabolite-responsive regulators for polyketide pathway engineering
合作研究:聚酮化合物途径工程的代谢物响应调节剂
- 批准号:
1159398 - 财政年份:2012
- 资助金额:
$ 63.57万 - 项目类别:
Continuing Grant
CAREER: Engineering Regulatory Protein Effector Specificity to Facilitate Combinatorial Library Analyses
职业:工程调节蛋白效应子特异性以促进组合文库分析
- 批准号:
1135710 - 财政年份:2011
- 资助金额:
$ 63.57万 - 项目类别:
Continuing Grant
CAREER: Engineering Regulatory Protein Effector Specificity to Facilitate Combinatorial Library Analyses
职业:工程调节蛋白效应子特异性以促进组合文库分析
- 批准号:
0644678 - 财政年份:2007
- 资助金额:
$ 63.57万 - 项目类别:
Continuing Grant
相似国自然基金
Frontiers of Environmental Science & Engineering
- 批准号:51224004
- 批准年份:2012
- 资助金额:20.0 万元
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Chinese Journal of Chemical Engineering
- 批准号:21224004
- 批准年份:2012
- 资助金额:20.0 万元
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Chinese Journal of Chemical Engineering
- 批准号:21024805
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:专项基金项目
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