Molecular Genetics of Ethylene-Auxin Interactions in Arabidopsis

拟南芥乙烯-生长素相互作用的分子遗传学

基本信息

  • 批准号:
    0519869
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-09-01 至 2009-08-31
  • 项目状态:
    已结题

项目摘要

Intellectual Merit. Hormones are key components in the orchestration of plant responses to developmental and environmental cues. The hormone-mediated integration process, although clearly established at the physiological level, is still largely unknown at the molecular level. This project identifies and characterizes specific points of interaction between the ethylene response and auxin biosynthetic pathway in the model plant Arabidopsis thaliana. The implications of these studies expand beyond the hormone crosstalk to the largely unknown auxin biosynthetic pathway and its regulation.Three new root-specific ethylene resistant mutants have been identified (wei2, wei7, and wei8). Cloning and characterization of wei2 and wei7 uncovered an unexpected role of a and b subunits of a tryptophan biosynthetic enzyme anthranilate synthase in the regulation of auxin biosynthesis. Similarly, initial characterization of WEI8 indicates that the WEI8 protein catalyzes the conversion of tryptophan to indole-3-pyruvic acid, a key step in auxin biosynthesis for which no genetic information was available previously. WEI8 belongs to a small multigenic family of 5 members in Arabidopsis. To further dissect the role of WEI8 and WEI8-like (WEL) genes in auxin biosynthesis, to understand their regulation by ethylene, and to identify additional genetic elements in the auxin biosynthetic pathway, the following specific goals are set. 1) Determine the role of WEI8 and its closest homologues WEL1 and WEL2 in the ethylene response. 2) Determine the role of WEI8, WEL1, and WEL2 in auxin biosynthesis. 3) Identify and characterize new wei mutants. Broader Impact. Modification of plant responses to specific hormones can be utilized to improve agricultural production. These manipulations often result in collateral adverse effects due to the diversity of functions that a single hormone has during development. Understanding of how a hormone produces completely different effects dependent on the tissue, developmental and environmental conditions, etc. is, therefore, critical for the intelligent manipulation of plant production. This project will provide basic information on the genetics of auxin biosynthesis, thus enabling people to effectively control the myriad of processes regulated by auxin in plants. An important part of the funds will be dedicated to training students and postdoctoral fellows in basic, as well as applied plant biology. As part of this training, all involved personnel will be able to attend scientific meetings to become exposed to the latest advances in the field of their research and share their own findings.
智力优势。激素是协调植物对发育和环境线索的反应的关键组成部分。虽然在生理水平上清楚地建立了酶介导的整合过程,但在分子水平上仍然很大程度上未知。本研究以模式植物拟南芥为研究对象,对乙烯反应与生长素生物合成途径之间的相互作用进行了研究。这些研究的意义超出了激素的串扰扩展到很大程度上未知的生长素生物合成途径及其调控。三个新的根特异性乙烯抗性突变体(wei 2,wei 7和wei 8)已被确定。wei 2和wei 7的克隆和表征揭示了色氨酸生物合成酶邻氨基苯甲酸合酶的a和B亚基在生长素生物合成调节中的意想不到的作用。类似地,WEI 8的初步表征表明WEI 8蛋白催化色氨酸转化为吲哚-3-烟酸,这是生长素生物合成中的关键步骤,之前没有遗传信息。WEI 8是拟南芥中一个由5个成员组成的多基因小家族。为了进一步剖析WEI 8和WEI 8-like(WEL)基因在生长素生物合成中的作用,理解乙烯对它们的调节,并鉴定生长素生物合成途径中的其他遗传元件,设定了以下具体目标。1)确定WEI 8及其最接近的同源物WEL 1和WEL 2在乙烯反应中的作用。2)确定WEI 8、WEL 1和WEL 2在生长素生物合成中的作用。3)识别和表征新的wei突变体。更广泛的影响。改变植物对特定激素的反应可用于提高农业生产。由于单一激素在发育过程中具有多种功能,这些操作通常会导致附带的不良影响。因此,了解激素如何根据组织、发育和环境条件等产生完全不同的效果,对于智能操纵植物生产至关重要。该项目将提供生长素生物合成遗传学的基本信息,从而使人们能够有效地控制植物中生长素调节的无数过程。资金的一个重要部分将专门用于培训学生和博士后研究员在基础,以及应用植物生物学。作为培训的一部分,所有相关人员都将能够参加科学会议,了解其研究领域的最新进展,并分享自己的发现。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jose Alonso其他文献

Recent issues on stochastic directional convexity, and new results on the analysis of systems for communication, information, time scales and maintenance
关于随机方向凸性的最新问题,以及通信、信息、时间尺度和维护系统分析的新结果
  • DOI:
    10.1002/asmb.1989
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Eva;Jose Alonso
  • 通讯作者:
    Jose Alonso
Comparison of multi-stage dose-response mixture models, with applications.
多阶段剂量反应混合模型的比较及其应用。
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Eva;Jose Alonso
  • 通讯作者:
    Jose Alonso
Assessing Simplifying Hypotheses in Density Estimation
评估密度估计中的简化假设
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jose Alonso
  • 通讯作者:
    Jose Alonso
Variability comparisons for some mixture models with stochastic environments in biosciences and engineering
生物科学和工程中一些具有随机环境的混合模型的变异性比较

Jose Alonso的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jose Alonso', 18)}}的其他基金

EAGER: TRTech-PGR: New methods to study gene-specific translation regulation
EAGER:TRTech-PGR:研究基因特异性翻译调控的新方法
  • 批准号:
    2327912
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
EAGER: Lambda-Red-enhanced homologous recombination in plants
EAGER:Lambda-Red 增强植物中的同源重组
  • 批准号:
    1940829
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Identification of Translational Hormone-Response Gene Networks and cis-Regulatory Elements
翻译激素反应基因网络和顺式调控元件的鉴定
  • 批准号:
    1444561
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
CONFERENCE: 24th International Conference on Arabidopsis Research to be held June 25-28, 2013 at the Convention and Exhibition Centre in Sydney, Australia
会议:第24届国际拟南芥研究会议将于2013年6月25日至28日在澳大利亚悉尼会展中心举行
  • 批准号:
    1314864
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Metabolic networks of auxin biosynthesis
生长素生物合成的代谢网络
  • 批准号:
    1158181
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Molecular Genetics of Ethylene-auxin Interactions in Arabidopsis
拟南芥乙烯-生长素相互作用的分子遗传学
  • 批准号:
    0923727
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Arabidopsis 2010: The Arabidopsis Localizome
拟南芥 2010:拟南芥定位组
  • 批准号:
    0820755
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
The Arecibo Geoscience Diversity Program: Enhancing the Education of Hispanics through Research Experiences
阿雷西博地球科学多样性计划:通过研究经验加强西班牙裔教育
  • 批准号:
    0303183
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
New Components of the Ethylene Signaling and Response Pathway
乙烯信号和响应途径的新成分
  • 批准号:
    0315992
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

相似国自然基金

Journal of Genetics and Genomics
  • 批准号:
    31224803
  • 批准年份:
    2012
  • 资助金额:
    24.0 万元
  • 项目类别:
    专项基金项目

相似海外基金

REU Site: Summer Undergraduate Research in Genetics and Genomics (SURGe)
REU 网站:遗传学和基因组学暑期本科生研究 (SURGe)
  • 批准号:
    2349410
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Using genetics to understand the role of hormones in postmenopausal health
利用遗传学了解激素在绝经后健康中的作用
  • 批准号:
    EP/Y031970/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
How the mushroom lost its gills: phylogenomics and population genetics of a morphological innovation in the fungal genus Lentinus
蘑菇如何失去鳃:香菇属真菌形态创新的系统基因组学和群体遗传学
  • 批准号:
    2333266
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
REU Site: Molecular Biology and Genetics of Cell Signaling
REU 网站:细胞信号传导的分子生物学和遗传学
  • 批准号:
    2349577
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Unravelling the genetics of Kangaroo paws for climate-resilient gardens
解开袋鼠爪子的遗传学,打造适应气候变化的花园
  • 批准号:
    IE230100040
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Early Career Industry Fellowships
Some like it hot: the genetics of rapid adaptation to climate change
有些人喜欢热:快速适应气候变化的遗传学
  • 批准号:
    DP240102637
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Discovery Projects
Using patient-led genetics to identify new therapeutic targets in metastatic cholangiocarcinoma
利用患者主导的遗传学来确定转移性胆管癌的新治疗靶点
  • 批准号:
    EP/Y028546/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
Combining structural biology and genetics to understand the function of a multi-gene family expanded in neglected human malaria parasites
结合结构生物学和遗传学来了解在被忽视的人类疟疾寄生虫中扩展的多基因家族的功能
  • 批准号:
    MR/Y012895/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
BIORETS: Genetics, Genomics, and Biology Research Experiences for Teachers in the Sciences
BIORETS:科学教师的遗传学、基因组学和生物学研究经验
  • 批准号:
    2341385
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Harnessing the interplay of genetics, cells, and matrix, to deliver insights into musculoskeletal health and new therapies in musculoskeletal disease
利用遗传学、细胞和基质的相互作用,深入了解肌肉骨骼健康和肌肉骨骼疾病的新疗法
  • 批准号:
    MR/Y030419/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了