Molecular Genetics of Ethylene-Auxin Interactions in Arabidopsis
拟南芥乙烯-生长素相互作用的分子遗传学
基本信息
- 批准号:0519869
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-01 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Intellectual Merit. Hormones are key components in the orchestration of plant responses to developmental and environmental cues. The hormone-mediated integration process, although clearly established at the physiological level, is still largely unknown at the molecular level. This project identifies and characterizes specific points of interaction between the ethylene response and auxin biosynthetic pathway in the model plant Arabidopsis thaliana. The implications of these studies expand beyond the hormone crosstalk to the largely unknown auxin biosynthetic pathway and its regulation.Three new root-specific ethylene resistant mutants have been identified (wei2, wei7, and wei8). Cloning and characterization of wei2 and wei7 uncovered an unexpected role of a and b subunits of a tryptophan biosynthetic enzyme anthranilate synthase in the regulation of auxin biosynthesis. Similarly, initial characterization of WEI8 indicates that the WEI8 protein catalyzes the conversion of tryptophan to indole-3-pyruvic acid, a key step in auxin biosynthesis for which no genetic information was available previously. WEI8 belongs to a small multigenic family of 5 members in Arabidopsis. To further dissect the role of WEI8 and WEI8-like (WEL) genes in auxin biosynthesis, to understand their regulation by ethylene, and to identify additional genetic elements in the auxin biosynthetic pathway, the following specific goals are set. 1) Determine the role of WEI8 and its closest homologues WEL1 and WEL2 in the ethylene response. 2) Determine the role of WEI8, WEL1, and WEL2 in auxin biosynthesis. 3) Identify and characterize new wei mutants. Broader Impact. Modification of plant responses to specific hormones can be utilized to improve agricultural production. These manipulations often result in collateral adverse effects due to the diversity of functions that a single hormone has during development. Understanding of how a hormone produces completely different effects dependent on the tissue, developmental and environmental conditions, etc. is, therefore, critical for the intelligent manipulation of plant production. This project will provide basic information on the genetics of auxin biosynthesis, thus enabling people to effectively control the myriad of processes regulated by auxin in plants. An important part of the funds will be dedicated to training students and postdoctoral fellows in basic, as well as applied plant biology. As part of this training, all involved personnel will be able to attend scientific meetings to become exposed to the latest advances in the field of their research and share their own findings.
智力优点。激素是协调植物对发育和环境线索的反应的关键组成部分。激素介导的整合过程虽然在生理水平上明确确立,但在分子水平上仍然很大程度上未知。该项目确定并表征了模式植物拟南芥中乙烯反应和生长素生物合成途径之间相互作用的特定点。这些研究的意义不仅限于激素串扰,还扩展到很大程度上未知的生长素生物合成途径及其调节。已经鉴定出三种新的根特异性乙烯抗性突变体(wei2、wei7 和 wei8)。 wei2 和 wei7 的克隆和表征揭示了色氨酸生物合成酶邻氨基苯甲酸合酶的 a 和 b 亚基在生长素生物合成调节中的意外作用。同样,WEI8 的初步表征表明,WEI8 蛋白催化色氨酸转化为吲哚-3-丙酮酸,这是生长素生物合成的关键步骤,之前没有可用的遗传信息。 WEI8 属于拟南芥中一个由 5 个成员组成的小型多基因家族。为了进一步剖析WEI8和WEI8样(WEL)基因在生长素生物合成中的作用,了解它们受乙烯的调节,并确定生长素生物合成途径中的其他遗传元件,设定了以下具体目标。 1) 确定WEI8及其最接近的同源物WEL1和WEL2在乙烯反应中的作用。 2)确定WEI8、WEL1和WEL2在生长素生物合成中的作用。 3) 鉴定和表征新的wei突变体。更广泛的影响。改变植物对特定激素的反应可用于提高农业产量。由于单一激素在发育过程中具有多种功能,这些操作通常会导致附带的不利影响。因此,了解激素如何根据组织、发育和环境条件等产生完全不同的效果对于植物生产的智能操纵至关重要。该项目将提供生长素生物合成的遗传学基础信息,从而使人们能够有效控制植物中生长素调控的无数过程。该资金的一个重要部分将专门用于培训基础和应用植物生物学的学生和博士后研究员。作为培训的一部分,所有相关人员都将能够参加科学会议,了解其研究领域的最新进展并分享自己的发现。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jose Alonso其他文献
Recent issues on stochastic directional convexity, and new results on the analysis of systems for communication, information, time scales and maintenance
关于随机方向凸性的最新问题,以及通信、信息、时间尺度和维护系统分析的新结果
- DOI:
10.1002/asmb.1989 - 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Eva;Jose Alonso - 通讯作者:
Jose Alonso
Comparison of multi-stage dose-response mixture models, with applications.
多阶段剂量反应混合模型的比较及其应用。
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:4.3
- 作者:
Eva;Jose Alonso - 通讯作者:
Jose Alonso
Assessing Simplifying Hypotheses in Density Estimation
评估密度估计中的简化假设
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Jose Alonso - 通讯作者:
Jose Alonso
Variability comparisons for some mixture models with stochastic environments in biosciences and engineering
生物科学和工程中一些具有随机环境的混合模型的变异性比较
- DOI:
10.1007/s00477-009-0310-6 - 发表时间:
2010 - 期刊:
- 影响因子:4.2
- 作者:
L. Escudero;Eva;Jose Alonso - 通讯作者:
Jose Alonso
Jose Alonso的其他文献
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{{ truncateString('Jose Alonso', 18)}}的其他基金
EAGER: TRTech-PGR: New methods to study gene-specific translation regulation
EAGER:TRTech-PGR:研究基因特异性翻译调控的新方法
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2327912 - 财政年份:2023
- 资助金额:
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EAGER: Lambda-Red-enhanced homologous recombination in plants
EAGER:Lambda-Red 增强植物中的同源重组
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1940829 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Standard Grant
Identification of Translational Hormone-Response Gene Networks and cis-Regulatory Elements
翻译激素反应基因网络和顺式调控元件的鉴定
- 批准号:
1444561 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Continuing Grant
CONFERENCE: 24th International Conference on Arabidopsis Research to be held June 25-28, 2013 at the Convention and Exhibition Centre in Sydney, Australia
会议:第24届国际拟南芥研究会议将于2013年6月25日至28日在澳大利亚悉尼会展中心举行
- 批准号:
1314864 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Standard Grant
Metabolic networks of auxin biosynthesis
生长素生物合成的代谢网络
- 批准号:
1158181 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Standard Grant
Molecular Genetics of Ethylene-auxin Interactions in Arabidopsis
拟南芥乙烯-生长素相互作用的分子遗传学
- 批准号:
0923727 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Standard Grant
Arabidopsis 2010: The Arabidopsis Localizome
拟南芥 2010:拟南芥定位组
- 批准号:
0820755 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Standard Grant
The Arecibo Geoscience Diversity Program: Enhancing the Education of Hispanics through Research Experiences
阿雷西博地球科学多样性计划:通过研究经验加强西班牙裔教育
- 批准号:
0303183 - 财政年份:2003
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-- - 项目类别:
Continuing Grant
New Components of the Ethylene Signaling and Response Pathway
乙烯信号和响应途径的新成分
- 批准号:
0315992 - 财政年份:2003
- 资助金额:
-- - 项目类别:
Continuing Grant
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- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
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