Molecular Genetics of Ethylene-auxin Interactions in Arabidopsis

拟南芥乙烯-生长素相互作用的分子遗传学

基本信息

批准号：
0923727
负责人：
Jose Alonso
金额：
$ 73.35万
依托单位：
North Carolina State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-15 至 2013-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923727&HistoricalAwards=false
关键词：
Molecular Genetics Ethylene auxin Interactions

项目摘要

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Intellectual MeritSurvival of plants largely depends on their ability to coordinate internal programs, such as growth and development, with the external conditions of the ever-changing environment. Understanding how plants integrate internal and external signals is critical for coping with the consequences of the global environmental changes facing our planet. It is becoming increasingly clear that interactions between different hormones (or hormones and other signaling pathways) are at the center of the signal integration process underlying the tremendous plasticity in plant characteristics required for their survival in hostile environments. While crosstalk between hormones and developmental signals occurs at several different levels, the regulation of hormone biosynthesis is emerging as one of the essential factors in signal integration biology. It is, therefore, paramount to decipher how hormones are synthesized, how their synthesis is regulated, and to determine the physiological significance of such regulation. In this project, several of the basic questions regarding biosynthesis of the essential plant hormone auxin will be addressed. The biological significance of local auxin biosynthesis in several well-defined developmental processes and in response to the stress hormone ethylene will be investigated. The relationship between different routes of auxin production (currently believed to be independent) will be examined. Finally, additional genes involved in auxin biosynthesis will be identified. The information gained from this project will be essential for the intelligent manipulation of specific plant responses to environmental factors for the benefit of agriculture and conservation biology. Broader ImpactsThe project targets students at all levels and includes outreach to students in elementary school, involvement of undergraduates in research, and postdoctoral mentoring. In addition there is a special effort for broadening participation by including students who are traditionally underrepresented in science. Specifically the PI will target the Hispanic community at North Carolina State University as well as students from North Carolina Central University, a historically black college. Minority students from both institutions will be recruited to participate in an existing Summer Research Experience for Undergraduates. To stimulate and foster interest in science in elementary school children, a bi-lingual (English and Spanish) experimental plan consisting of several "do-it-yourself" biology modules for children will be developed. To facilitate parental dialogue with students the science experiments will be described in brochures that students can share with their parents.

该奖项是根据2009年的《美国复苏与再投资法》（公法111-5）资助的。植物的智能优异存在在很大程度上取决于其协调内部计划的能力，例如增长和发展，以及不断变化的环境的外部条件。了解植物如何整合内部和外部信号对于应对我们星球面临的全球环境变化的后果至关重要。越来越清楚的是，不同激素（或激素和其他信号通路）之间的相互作用位于信号整合过程的中心，这是其在敌对环境中生存所需的植物特征中巨大可塑性的基础。虽然激素之间的串扰和发育信号之间发生在几个不同的水平上，但激素生物合成的调节正在成为信号整合生物学的基本因素之一。因此，这对于破译激素的合成方式，如何调节其合成以及确定这种调节的生理意义至关重要。在这个项目中，将解决有关基本植物激素生长素生物合成的一些基本问题。将研究局部生长素生物合成在几个定义明确的发育过程中的生物学意义，并响应应力激素乙烯。将检查生长素生产的不同途径（当前认为是独立的）之间的关系。最后，将鉴定出参与生长素生物合成的其他基因。从该项目中获得的信息对于智能操纵对环境因素的特定响应至关重要，以使农业和保护生物学的利益受益。更广泛的影响该项目针对各个级别的学生，包括向小学的学生推广，本科生参与研究和博士后指导。此外，通过包括传统上代表不足的科学人数不足的学生，也有特别的努力来扩大参与。特别是，PI将针对北卡罗来纳州立大学的西班牙裔社区以及北卡罗来纳州中央大学的学生，这是一所历史悠久的黑人学院。来自两个机构的少数族裔学生将被招募，以参加本科生的现有夏季研究经验。为了刺激和促进对小学儿童科学的兴趣，将制定一项双语（英语和西班牙语）实验计划，该计划将开发由几个儿童的“自己动手”的生物学模块组成。为了促进与学生的父母对话，科学实验将在学生可以与父母分享的小册子中进行描述。