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Molecular Genetics of Ethylene-auxin Interactions in Arabidopsis

拟南芥乙烯-生长素相互作用的分子遗传学

基本信息

批准号：
0923727
负责人：
Jose Alonso
金额：
$ 73.35万
依托单位：
North Carolina State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-15 至 2013-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923727&HistoricalAwards=false
关键词：
Molecular Genetics Ethylene auxin Interactions

项目摘要

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Intellectual MeritSurvival of plants largely depends on their ability to coordinate internal programs, such as growth and development, with the external conditions of the ever-changing environment. Understanding how plants integrate internal and external signals is critical for coping with the consequences of the global environmental changes facing our planet. It is becoming increasingly clear that interactions between different hormones (or hormones and other signaling pathways) are at the center of the signal integration process underlying the tremendous plasticity in plant characteristics required for their survival in hostile environments. While crosstalk between hormones and developmental signals occurs at several different levels, the regulation of hormone biosynthesis is emerging as one of the essential factors in signal integration biology. It is, therefore, paramount to decipher how hormones are synthesized, how their synthesis is regulated, and to determine the physiological significance of such regulation. In this project, several of the basic questions regarding biosynthesis of the essential plant hormone auxin will be addressed. The biological significance of local auxin biosynthesis in several well-defined developmental processes and in response to the stress hormone ethylene will be investigated. The relationship between different routes of auxin production (currently believed to be independent) will be examined. Finally, additional genes involved in auxin biosynthesis will be identified. The information gained from this project will be essential for the intelligent manipulation of specific plant responses to environmental factors for the benefit of agriculture and conservation biology. Broader ImpactsThe project targets students at all levels and includes outreach to students in elementary school, involvement of undergraduates in research, and postdoctoral mentoring. In addition there is a special effort for broadening participation by including students who are traditionally underrepresented in science. Specifically the PI will target the Hispanic community at North Carolina State University as well as students from North Carolina Central University, a historically black college. Minority students from both institutions will be recruited to participate in an existing Summer Research Experience for Undergraduates. To stimulate and foster interest in science in elementary school children, a bi-lingual (English and Spanish) experimental plan consisting of several "do-it-yourself" biology modules for children will be developed. To facilitate parental dialogue with students the science experiments will be described in brochures that students can share with their parents.

该奖项根据 2009 年美国复苏和再投资法案（公法 111-5）提供资金。智力优势植物的生存在很大程度上取决于它们协调内部计划（例如生长和发展）与不断变化的环境的外部条件的能力。了解植物如何整合内部和外部信号对于应对地球面临的全球环境变化的后果至关重要。越来越清楚的是，不同激素（或激素和其他信号通路）之间的相互作用是信号整合过程的核心，这是植物在恶劣环境中生存所需的特性的巨大可塑性的基础。虽然激素和发育信号之间的串扰发生在几个不同的水平，但激素生物合成的调节正在成为信号整合生物学的重要因素之一。因此，至关重要的是破译激素是如何合成的，它们的合成是如何调节的，并确定这种调节的生理意义。在该项目中，将解决有关必需植物激素生长素生物合成的几个基本问题。将研究局部生长素生物合成在几个明确的发育过程中以及对应激激素乙烯的反应中的生物学意义。将检查不同生长素生产途径之间的关系（目前认为是独立的）。最后，将鉴定参与生长素生物合成的其他基因。从该项目获得的信息对于智能操纵特定植物对环境因素的反应至关重要，以造福于农业和保护生物学。更广泛的影响该项目针对各个级别的学生，包括对小学学生的宣传、本科生参与研究以及博士后指导。此外，还特别努力扩大参与范围，包括传统上在科学领域代表性不足的学生。具体而言，PI 将针对北卡罗来纳州立大学的西班牙裔社区以及北卡罗来纳中央大学（一所历史悠久的黑人大学）的学生。来自这两个机构的少数民族学生将被招募参加现有的本科生暑期研究体验。为了激发和培养小学生对科学的兴趣，将制定一个双语（英语和西班牙语）实验计划，其中包括几个供儿童“自己动手”的生物模块。为了促进家长与学生的对话，科学实验将在小册子中描述，学生可以与家长分享。