MRI: Acquisition of Integrated Electron Microscopy, Tomography and Computational Resources Supporting Interdisciplinary Collaboration in Research and Education at USM

该项目获得了一台集成了高性能并行计算集群(HPC)的透射式电子显微镜(TEM)，促进了与结构应用程序接口的加速三维图像分析的创新。该基础设施支持南缅因州大学(USM)、新英格兰大学(UNE)和缅因州医学中心研究所(MMCRI)四个地区校区的跨学科和生物信息学研究和教育，专门针对高效的断层图像采集、3-D重建、数据存储和系统建模应用。它允许目前的研究人员在复杂的跨学科研究中有效地合作，涉及协调使用：-基因组学的广泛数据，-转录阵列分析，-蛋白质组学和新陈代谢组学，-人口生物学和生物多样性调查研究，以及-高级环境建模。更广泛的影响：协同教育努力(GK-12奖)目前正在作为合作研究经验和积极学习研究所的一部分得到维持，该研究所由一个联合PI指导。这个基础设施，连同开发的计算生物学课程，为USM、UNE、MMCRI的学生提供培训。此外，与TEM和HPC设施的远程连接使农村高中的噬菌体生态学和基因组学项目成为可能。

This project, acquiring a transmission electron microscope (TEM) integrated with a high-performance parallel computing cluster (HPC), fosters innovation in accelerated 3-D image analysis interfaced with structural applications. Supporting interdisciplinary and bioinformatics research and education at four regional campuses of the University of Southern Maine (USM), as well as the University of New England (UNE), and the Maine Medical Center Research Institute (MMCRI), the infrastructure is specifically aimed at efficient tomographic image acquisition, 3-D reconstruction, data storage, and system modeling applications. It allows current investigators to collaborate effectively in complex interdisciplinary research involving coordinated use of:-Extensive data on genomics,-Transcriptional array analysis,-Proteomics and Metabolomics,-Population Biology, and Biodiversity survey research, and-Advanced environmental modeling.Benefiting numerous research projects in the region, the HPC support is expected to accelerate image acquisition, provide bioinformatics resources, and enable interdisciplinary investigation in complex systems. Broader Impact: Synergistic educational efforts (GK-12 award) are presently being sustained as part of the Institute for Collaborative Research Experiences and Active Learning directed by a Co-PI. This infrastructure, along with the computational biology courses developed, provides training for students at USM, UNE, MMCRI. Moreover, the remote connection with the TEM and HPC facility enables projects in bacteriophage ecology and genomics in rural high schools.