Acqusition of an LC/MS to Facilitate Collaboration and Faculty-Undergraduate Research at the University of Portland, Lewis & Clark College and Portland Veterans Medical Center

波特兰大学的化学和物理系将从主要研究仪器(MRI)计划获得这一奖项，从而获得一台液体色谱仪/质谱仪(LC/MS)。该设备将与刘易斯与克拉克学院和波特兰退伍军人医疗中心的研究人员共享。它将加强多个领域的研究，包括a)天然产物研究，b)植物与环境之间的化学通讯，c)参与紫杉烷、类胡萝卜素和甾醇合成的生化途径的调节，d)微生物介导的环境过程的机理和动力学的阐明，e)萜类和芳香族化合物的表征，f)茂钼化合物的水解研究，g)抗疟疾药物先导化合物的筛选和优化。这一仪器将大大加强波特兰大学的科学研究，波特兰大学是一所以本科为主的机构。这些研究将在生物化学、环境化学和药物化学领域产生坚实的影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Physics at the University of Portland will acquire a liquid chromatograph/mass spectrometer (LC/MS). This equipment will be shared with researchers from Lewis & Clark College and Portland Veterans Medical Center. It will enhance research in a number of areas including a) natural product research, b) chemical communications between plants and their environment, c) regulation of biochemical pathways involved in synthesis of taxanes, carotenoids and sterols, d) elucidation of the mechanisms and kinetics of microbially mediated environmental processes, e) characterization of terpenoids and aromatic compounds, f) studies of hydrolysis of molybdenum metallocenes, and g) the screening and optimization of leads for antimalarial drugs.Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at the University of Portland, a primarily undergraduate institution. These studies will have a solid impact in the area of biochemistry, environmental chemistry and medicinal chemistry.