Acqusition of an LC/MS to Facilitate Collaboration and Faculty-Undergraduate Research at the University of Portland, Lewis & Clark College and Portland Veterans Medical Center

获得 LC/MS 以促进刘易斯波特兰大学的合作和师生研究

• 批准号: 0521648
• 负责人: Angela Hoffman
• 金额: $ 18.23万
• 依托单位: University of Portland
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521648&HistoricalAwards=false
• 关键词: Acqusition; LC; MS; Facilitate; Collaboration

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Physics at the University of Portland will acquire a liquid chromatograph/mass spectrometer (LC/MS). This equipment will be shared with researchers from Lewis & Clark College and Portland Veterans Medical Center. It will enhance research in a number of areas including a) natural product research, b) chemical communications between plants and their environment, c) regulation of biochemical pathways involved in synthesis of taxanes, carotenoids and sterols, d) elucidation of the mechanisms and kinetics of microbially mediated environmental processes, e) characterization of terpenoids and aromatic compounds, f) studies of hydrolysis of molybdenum metallocenes, and g) the screening and optimization of leads for antimalarial drugs.Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at the University of Portland, a primarily undergraduate institution. These studies will have a solid impact in the area of biochemistry, environmental chemistry and medicinal chemistry.

有了这个主要研究仪器（MRI）计划的奖项，波特兰大学化学和物理系将获得液相色谱/质谱仪（LC/MS）。这些设备将与来自刘易斯克拉克学院和波特兰退伍军人医疗中心的研究人员共享。 它将加强若干领域的研究，包括a）天然产物研究，B）植物与其环境之间的化学通讯，c）紫杉烷、类胡萝卜素和甾醇合成所涉及的生物化学途径的调节，d）阐明微生物介导的环境过程的机制和动力学，e）萜类化合物和芳香化合物的特性，f）钼烯水解的研究，g）抗疟疾药物先导化合物的筛选和优化液相色谱-质谱检测（LC/MS）是一种非常强大的技术，用于分离和分析复杂的混合物。这一工具将大大加强波特兰大学的科学研究，该大学主要是本科院校。 这些研究将对生物化学、环境化学和药物化学领域产生坚实的影响。