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Molecular Analysis of Meiotic Recombination in the Bronze Genomic Region of Maize

玉米青铜基因组区域减数分裂重组的分子分析

基本信息

批准号：
0523103
负责人：
Hugo Dooner
金额：
$ 58.47万
依托单位：
Rutgers University New Brunswick
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2009-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0523103&HistoricalAwards=false
关键词：
Molecular Analysis Meiotic Recombination Bronze

项目摘要

Homologous meiotic recombination is an important process because it creates new genotypes by shuffling chromosomal segments that otherwise would be inherited as blocks and promotes fertility by ensuring that chromosomes segregate properly. Recombination allows the construction of genetic maps, which are used in risk prediction for inherited disorders, in marker-assisted selection of desirable genotypes in agriculture, and in map-based cloning of valuable genes in plants. This project will increase our understanding of homologous meiotic recombination in maize, which is an excellent model organism for studies of recombination and has economic importance to American agriculture and industry. Much of the work is based on the discovery in the PI's lab of an unprecedented level of haplotype variability in maize. The project aims to study how recombination is affected by it. The project will continue to analyze meiotic recombination in maize by combining the power of the genetics of the bz region with that of modern molecular tools. The project is relevant to U.S. agriculture in that it studies meiotic recombination, the phenomenon underlying most plant breeding. The project will be staffed by members of under-represented minorities and will serve as excellent training ground for undergraduate students interested in learning modern genotyping techniques. The P.I. himself is actively involved in collaborations with scientists from developing countries.

同源减数分裂重组是一个重要的过程，因为它通过重组染色体片段来创造新的基因型，否则染色体片段将作为块遗传，并通过确保染色体正确分离来促进生育。重组允许构建遗传图谱，用于遗传疾病的风险预测，用于农业中理想基因型的标记辅助选择，以及用于植物中有价值基因的图谱克隆。该项目将增加我们对玉米同源减数分裂重组的认识，这是一个很好的重组研究模式生物，对美国农业和工业具有重要的经济意义。大部分工作都是基于PI实验室发现的玉米单倍型变异达到前所未有的水平。该项目旨在研究它是如何影响重组的。该项目将继续通过结合bz地区遗传学的力量和现代分子工具的力量来分析玉米的减数分裂重组。该项目与美国农业相关，因为它研究减数分裂重组，这是大多数植物育种的基础现象。该项目将由代表性不足的少数民族成员担任工作人员，并将成为对学习现代基因分型技术感兴趣的本科生的优秀培训基地。私家侦探本人也积极参与与发展中国家科学家的合作。