Molecular Analysis of Meiotic Recombination in the Bronze Genomic Region of Maize

同源减数分裂重组是一个重要的过程，因为它通过改组原本会作为区块遗传的染色体片段来创造新的基因类型，并通过确保染色体正确分离来促进生育。重组可以构建遗传图谱，用于遗传性疾病的风险预测，用于标记辅助选择农业中所需的基因类型，以及基于图谱克隆植物中有价值的基因。玉米同源减数分裂重组是研究重组的理想模式生物，对美国农业和工业具有重要的经济意义。许多工作都是基于国际玉米研究所实验室发现的前所未有的玉米单倍型变异水平。该项目旨在研究重组是如何受其影响的。该项目将继续通过结合BZ区遗传学的力量和现代分子工具来分析玉米的减数分裂重组。该项目与美国农业相关，因为它研究减数分裂重组，这是大多数植物育种的基础现象。该项目将由代表性不足的少数族裔成员组成，并将成为对学习现代基因分型技术感兴趣的本科生的极好培训基地。私家侦探本人也积极参与与发展中国家科学家的合作。

Homologous meiotic recombination is an important process because it creates new genotypes by shuffling chromosomal segments that otherwise would be inherited as blocks and promotes fertility by ensuring that chromosomes segregate properly. Recombination allows the construction of genetic maps, which are used in risk prediction for inherited disorders, in marker-assisted selection of desirable genotypes in agriculture, and in map-based cloning of valuable genes in plants. This project will increase our understanding of homologous meiotic recombination in maize, which is an excellent model organism for studies of recombination and has economic importance to American agriculture and industry. Much of the work is based on the discovery in the PI's lab of an unprecedented level of haplotype variability in maize. The project aims to study how recombination is affected by it. The project will continue to analyze meiotic recombination in maize by combining the power of the genetics of the bz region with that of modern molecular tools. The project is relevant to U.S. agriculture in that it studies meiotic recombination, the phenomenon underlying most plant breeding. The project will be staffed by members of under-represented minorities and will serve as excellent training ground for undergraduate students interested in learning modern genotyping techniques. The P.I. himself is actively involved in collaborations with scientists from developing countries.