SGER: PROGESTERONE AND SEXUAL DIFFERENTIATION OF BRAIN AND BEHAVIOR
SGER:黄体酮与大脑和行为的性别分化
基本信息
- 批准号:0527950
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-01 至 2008-02-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In most adult mammals, the ability to demonstrate effective patterns of reproductive physiology and behavior is the result of exposure during fetal life to hormones such as estradiol and testosterone produced by the fetus' developing gonads. However, the mammalian fetus is also exposed to another hormone, progesterone, which is produced by the maternal ovaries and the placenta during pregnancy. The effects of this exposure are unclear at this time, but recent evidence suggests that progesterone may actually masculinize the brain and later impact behavioral responses. Marsupial mammals offer a unique opportunity to directly explore the effects of progesterone on fetal development. Because marsupial mammals are very premature at birth compared to other mammals, much of their early development takes place outside the body of the mother, in an environment that is relatively free of progesterone. Therefore, marsupials are particularly useful for the study of reproductive development. With this animal model the effects of progesterone can be tightly controlled and directly measured, in the absence of maternal hormonal influences. Gray short tailed opossums (Monodelphis domestica), small, gerbil-sized laboratory marsupials, will be used here to characterize the effects of progesterone on the development of masculine and feminine characteristics and behavior in mammals. Opossums will be exposed to different amounts of progesterone soon after birth. When they are adults their behavior will be observed and hormone levels in their blood will be measured. It is expected that early exposure to progesterone will decrease feminine hormonal and behavioral traits in adult animals. Progesterone has wide effects on reproductive processes and brain function. It is already known that progesterone maintains pregnancy, activates reproductive and parental behavior and affects learning and memory. The new researchin this project will further extend our understanding of the role of this important hormone as it impacts reproductive development. This project will also provide a wide range of unique training opportunities for undergraduate and graduate students with Dr. Harder at the Ohio State University (OSU) and with Dr. Fadem at the University of Medicine and Dentistry of New Jersey (UMDNJ).
在大多数成年哺乳动物中,表现出有效的生殖生理和行为模式的能力是在胎儿期暴露于胎儿发育中的性腺产生的雌二醇和睾酮等激素的结果。然而,哺乳动物胎儿也会接触另一种激素——黄体酮,它是在怀孕期间由母体卵巢和胎盘产生的。 目前尚不清楚这种暴露的影响,但最近的证据表明,黄体酮实际上可能使大脑男性化,并随后影响行为反应。 有袋类哺乳动物为直接探索黄体酮对胎儿发育的影响提供了独特的机会。 由于与其他哺乳动物相比,有袋类哺乳动物出生时非常早产,因此它们的早期发育大部分发生在母体体外、相对不含黄体酮的环境中。因此,有袋动物对于生殖发育的研究特别有用。 通过这种动物模型,在没有母体激素影响的情况下,可以严格控制和直接测量黄体酮的影响。 灰色短尾负鼠(Monodelphis Domestica)是一种小型沙鼠大小的实验室有袋动物,将用于表征黄体酮对哺乳动物男性和女性特征和行为发育的影响。负鼠在出生后不久就会接触不同量的黄体酮。当他们成年后,他们的行为将被观察,血液中的激素水平将被测量。预计早期接触黄体酮会降低成年动物的雌性荷尔蒙和行为特征。 黄体酮对生殖过程和大脑功能具有广泛的影响。众所周知,黄体酮可以维持妊娠,激活生殖和养育行为,并影响学习和记忆。该项目的新研究将进一步加深我们对这种重要激素影响生殖发育的作用的理解。该项目还将为本科生和研究生提供广泛的独特培训机会,由哈德博士在俄亥俄州立大学 (OSU) 和法德姆博士在新泽西医学和牙科大学 (UMDNJ) 授课。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Harder其他文献
John Harder的其他文献
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{{ truncateString('John Harder', 18)}}的其他基金
SGER: Pheromonal Induction of Estrus and Ovulation in a Marsupial
SGER:有袋动物发情和排卵的信息素诱导
- 批准号:
9616588 - 财政年份:1996
- 资助金额:
-- - 项目类别:
Standard Grant
Ovarian Control of Parturition and Postpartum Estrus in the Tammar Wallaby
塔玛袋鼠的卵巢对分娩和产后发情的控制
- 批准号:
8200336 - 财政年份:1982
- 资助金额:
-- - 项目类别:
Standard Grant
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24380064 - 财政年份:2012
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Grant-in-Aid for Scientific Research (B)
SGER: PROGESTERONE AND SEXUAL DIFFERENTIATION OF BRAIN AND BEHAVIOR
SGER:黄体酮与大脑和行为的性别分化
- 批准号:
0528174 - 财政年份:2005
- 资助金额:
-- - 项目类别:
Continuing Grant
Progesterone and the Neural Mechanisms of Sexual Behavior
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- 批准号:
8607864 - 财政年份:1986
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