Collaborative Research: CBC: Center for Molecular Cybernetics

有了这个化学键中心(CBC)第一阶段，第二步奖，化学司和数学和物理科学局的多学科活动办公室共同支持哥伦比亚大学的米兰·N·斯托贾诺维奇的研究，他将领导一个由来自不同机构的八个PI参与的合作努力，以创建一个分子控制论中心。该中心的统一目标是生产由分子键形成提供动力的合成分子机器。具有两个或更多突出的DNA附属物的化学结构将被合成。这些附属物，或分子蜘蛛的手臂，将有能力对外部刺激做出反应，附着或脱离表面的某个位置。当蜘蛛手臂重新连接到不同的位置时，蜘蛛将在表面上移动。这些自主运动分子的成功构建和描述将引起科学和公众的兴趣，这些研究有可能导致在药物输送和纳米粒子等领域的应用。化学键合中心旨在集中创新的合作努力，解决一个将导致化学或化学与其他科学的接口的重大进展的“大问题”，并将有可能吸引广泛的科学和公众兴趣。

With this Chemical Bonding Center (CBC) Phase I, Step II award, the Division of Chemistry and the Office of Multidisciplinary Activities of the Mathematical and Physical Sciences Directorate jointly support the research of Milan N. Stojanovic, of Columbia University, who will lead a collaborative effort involving eight PIs from a variety of institutions to create a Center for Molecular Cybernetics. The unified goal of this center is to produce synthetic molecular machines that are powered by molecular bond formation. Chemical structures that will have two or more protruding appendages of DNA will be synthesized. These appendages, or arms of molecular "spiders", will have the ability to attach to or detach from a position on a surface in response to external stimulus. When a spider arm reattaches to a different position, the spider will move across the surface. The successful construction and description of these autonomously moving molecules will generate both scientific and public interest, and these studies have the potential to lead to applications in areas such as drug delivery and nanopatterning. Chemical Bonding Centers are designed to focus innovative collaborative efforts that address a "big problem" which will lead to a major advance in chemistry or at the interface of chemistry and other sciences and will have the potential to attract broad scientific and public interest.