Engineering Research Center (ERC) for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical Applications(C-SOC)

医药、保健品和农用化学品应用结构化有机复合材料工程研究中心 (ERC) (C-SOC)

• 批准号: 0540855
• 负责人: Fernando Muzzio
• 金额: $ 1497万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0540855&HistoricalAwards=false
• 关键词: Engineering; Research; Center; ERC; Structured

Project Summary0540855Background: The proposed ERC in Structured Organic Composites (C-SOC) will establish cutting-edge research, technology transfer, and educational/outreach to transform products and processes used for pharmaceutical, nutraceutical, and agrochemical delivery applications. The participating institutions have been carefully selected for their combined strengths in Pharmaceutical Engineering and in Nutraceuticals (Rutgers), Organic Nanomaterials (NJIT), and Industrial Pharmacy and Systems Engineering (Purdue) and Pharmaceutical Manufacturing (UPRM). Our main outreach institution, CCYN, provides additional strengths in particle synthesis, as well as further involvement of minorities through its LSAMP and AGEP programs. Intellectual Merit: Product and process design in organic composites is mostly empirical due to the underlying complexity of processes and products. The intellectual goal of C-SOC is to transform this technology domain into a science-based enterprise. In order to develop a predictive understanding of the effects of material properties and process parameters on the functionality and performance of organic delivery systems, interconnected research projects will be organized into three thrust areas: (1) Materials Synthesis and Functionalization, (2) Composite Synthesis and Characterization, and (3) Manufacturing Science. Research will focus on developing the means for systematic materials functionalization and structuring, rigorous process scale-up, process optimization and control strategies that will revolutionize product and process design and development in the target industries.Broader Impact: Improvements in this area will result in reduced cost and more consistent and reliable manufacture of biocompatible products as well as science-based, faster development of new products, and a more competitive US industry. Impact will be maximized by focusing on six technology test beds (integrated manufacturing platforms) that focus on multiple methodologies for synthesis of functionalized materials and finished products. To maximize technology transfer, the interconnected test beds will be organized into three materials development programs that cut across thrusts while following the typical product life cycle of the target industries: (1) Engineered Particulate Ingredients (crystals, precipitates, polymer nanoparticles) (2) Granular Micro-Composites (coated porous granular matrices), and (3) Macro-Composites (tablets, wafers, pellets).Education, Outreach: Modernization of academic programs in relevant areas at all levels will be achieved via educational programs, both formal and experiential, based on a flexible system of 1-credit modules that provide innovative content in a scalable, portable format suitable for a wide variety of audiences ranging from HS teachers to graduate students to continuing education participants. Graduate education will be enhanced by the development of a 15-credit graduate training program in structured organic composites. Impact at the Undergraduate level will be accomplished by the organization of minor and certificate programs in Engineering, Chemistry, Pharmacy, and Food Science, REU activities, a student exchange and summer internship programs. K-12 outreach will focus on a structured 4-stage awareness development program including a RET program, a summer research internship (Camp Pharma), and a traveling "lab on wheels" that introduces kids to engineering using demonstrations delivered in both English and Spanish.Diversity Development: The aforementioned programs will synergize efforts that specifically target individuals from historically underrepresented populations (e.g. Midwest Crossroads AGEP, The Puerto Rico LSAMP). Strong minority access is also given by UPR participation, and by a comprehensive plan for minority recruitment and retention, including exchanges with minority-serving institutions, internship programs, advertisement campaigns in appropriate college newspaper. Many of the proposed ERC faculty members come from historically underrepresented populations and will serve as mentors and role models.Industrial Participation: Industry will participate in the core research program using the multi-tiered memberships promoted by NSF. Approximately $1 million in (14) cash memberships has been committed to the proposed center. The ERC will also host company-specific research projects; additional cash funds also in excess to $1.6 million have been committed for this purpose by 24 companies. Active industrial participation in educational activities will be promoted by implementing internship programs and industrial participation in teaching activities, research, and mentoring.

项目概要0540855背景：拟议的结构化有机复合材料（C-SOC）ERC将建立尖端研究、技术转让和教育/推广，以改造用于制药、营养保健品和农用化学品输送应用的产品和工艺。 参与机构是根据其在制药工程和营养保健品（罗格斯大学），有机纳米材料（NJIT），工业制药和系统工程（普渡大学）和制药制造（UPRM）的综合优势精心挑选的。 我们的主要外展机构CCYN在粒子合成方面提供了额外的优势，并通过其LSAMP和AGEP计划进一步参与少数民族。 智力优势：由于工艺和产品的潜在复杂性，有机复合材料的产品和工艺设计大多是经验性的。 C-SOC的智力目标是将这一技术领域转变为以科学为基础的企业。 为了发展对材料特性和工艺参数对有机输送系统的功能和性能的影响的预测性理解，相互关联的研究项目将分为三个主要领域：（1）材料合成和功能化，（2）复合材料合成和表征，以及（3）制造科学。 研究将集中于开发系统的材料功能化和结构化、严格的工艺放大、工艺优化和控制策略的方法，这些方法将彻底改变目标行业的产品和工艺设计和开发。这一领域的改进将导致生物相容性产品的成本降低，生产更加一致和可靠，以及新产品的科学快速开发，更有竞争力的美国产业。 将通过侧重于六个技术试验台（综合制造平台）来最大限度地发挥影响，这些试验台侧重于合成功能化材料和成品的多种方法。 为了最大限度地实现技术转让，相互关联的试验台将被组织成三个材料开发项目，这些项目将跨越目标行业的典型产品生命周期：（1）工程颗粒成分（晶体、沉淀物、聚合物纳米颗粒）（2）颗粒状微复合材料（涂覆的多孔颗粒基质），和（3）宏观复合材料（片剂、薄饼、颗粒）。各级相关领域学术课程的现代化将通过正式和体验式教育方案实现，基于1学分模块的灵活系统，以可扩展的便携式格式提供创新内容，适合从HS教师到研究生再到继续教育参与者的各种受众。 研究生教育将通过开发15学分的结构化有机复合材料研究生培训计划来加强。 在本科层次的影响将通过在工程，化学，药学和食品科学，REU活动，学生交流和暑期实习计划的未成年人和证书课程的组织完成。 K-12外展将侧重于结构化的4阶段意识发展计划，包括RET计划，夏季研究实习（Camp Pharma），以及一个流动的“车轮上的实验室”，通过英语和西班牙语的演示向孩子们介绍工程学。上述方案将协同努力，专门针对历史上代表性不足的人口的个人（例如，中西部十字路口AGEP、波多黎各LSAMP）。 通过普遍定期审议的参与，以及招聘和留住少数群体的全面计划，包括与少数群体服务机构的交流、实习方案、在适当的大学报纸上的广告宣传，也使少数群体有更多的机会。 许多拟议的ERC教师来自历史上代表性不足的人群，将作为导师和榜样。行业参与：行业将参与核心研究计划使用由NSF推动的多层次会员资格。 大约100万美元的现金会员资格（14）已承诺向拟议的中心。 该研究中心还将主办针对具体公司的研究项目; 24家公司已承诺为此目的提供超过160万美元的额外现金资金。 将通过实施实习计划和工业参与教学活动、研究和指导来促进工业积极参与教育活动。

项目成果

Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing intensity

客体和主体粒径对干涂层效果的影响：何时不使用高混合强度

• DOI: 10.1016/j.powtec.2020.02.059
• 发表时间: 2020
• 期刊: Powder Technology
• 影响因子: 5.2
• 作者: Zheng, Kai;Kunnath, Kuriakose;Ling, Zhipeng;Chen, Liang;Davé, Rajesh N.
• 通讯作者: Davé, Rajesh N.