Molecular investigation of vascular lumen formation in the developing mouse aorta
发育中的小鼠主动脉血管腔形成的分子研究
基本信息
- 批准号:173903746
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2010
- 资助国家:德国
- 起止时间:2009-12-31 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Blood vessels are multicellular tubes with a central vascular lumen that provides tissues with oxygen, nutrients as well as developmental signals (Lammert et al., 2001). Despite their importance for embryonic development and adult life, the molecular mechanism remains fragmentary by which vascular endothelial cells assemble to form lumenized vascular tubes, thus allowing blood flow to and from each tissue. Our recent data demonstrate that, in developing mouse embryos, aortic endothelial cells form multicellular cords, in which the endothelial cells partially deadhere and separate from each other to form a vascular lumen between them (Strilic et al., 2009). Here we want to study the role of anti-adhesive CD34-sialomucins as well as the role of VEGF and Eph receptor mediated endothelial cell separation during formation of the aorta, the largest arterial blood vessel in all mammals and humans.
血管是具有中央血管腔的多细胞管,其为组织提供氧气、营养物以及发育信号(Lammert等人,2001年)。尽管它们对胚胎发育和成年生活很重要,但血管内皮细胞组装形成管腔化血管管的分子机制仍然是不完整的,从而允许血液流入和流出每个组织。我们最近的数据表明,在发育中的小鼠胚胎中,主动脉内皮细胞形成多细胞索,其中内皮细胞部分死亡并彼此分离以在它们之间形成血管腔(Strilic等人,2009年)。在这里,我们想研究的作用,抗粘附CD 34-唾液酸粘蛋白以及VEGF和Eph受体介导的内皮细胞分离的作用,在形成的主动脉,最大的动脉血管在所有哺乳动物和人类。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pharmacological manipulation of blood and lymphatic vascularization in ex vivo–cultured mouse embryos
- DOI:10.1038/nprot.2012.120
- 发表时间:2012-10
- 期刊:
- 影响因子:14.8
- 作者:Martin Zeeb;Jennifer Axnick;L. Planas-Paz;Thorsten Hartmann;Boris Strilic;E. Lammert
- 通讯作者:Martin Zeeb;Jennifer Axnick;L. Planas-Paz;Thorsten Hartmann;Boris Strilic;E. Lammert
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Professor Dr. Eckhard Lammert其他文献
Professor Dr. Eckhard Lammert的其他文献
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{{ truncateString('Professor Dr. Eckhard Lammert', 18)}}的其他基金
Investigation of the role of blood vessel endothelium in blood glucose metabolism
血管内皮在血糖代谢中的作用研究
- 批准号:
226258562 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Research Grants
Role of beta1-integrin signaling in lymphatic vessel formation
β1-整合素信号在淋巴管形成中的作用
- 批准号:
192924567 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Research Grants
Investigation of Ephrin-A Reverse Signaling in Pancreatic Islets
胰岛中 Ephrin-A 反向信号传导的研究
- 批准号:
61027617 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Research Grants
Interactions between blood vessel endothelium and pancreatic epithelium
血管内皮和胰腺上皮之间的相互作用
- 批准号:
5398766 - 财政年份:2003
- 资助金额:
-- - 项目类别:
Research Grants
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