CAREER: Axon Guidance by Multiple Cues

神经损伤后不能再生，目前的医学实践无法有效地操纵神经再生的过程。这个项目将量化指导线索，无论是单独的还是组合的，如何促进轴突的生长。研究结果将有助于理解神经发育和准确有效的神经再生。本研究的目的是利用微加工和微流体技术，研究轴突受多种因素的引导，包括表面上的地形和特定分子。该教育计划的重点是提高本科生和研究生一年级学生的口头沟通能力，即公开演讲能力。首席研究员（PI）所教的两个班的学生将为非科学观众举办研讨会。PI还将举办一个研讨会，帮助教师在课堂上教授沟通技巧。

Hoffman-Kim0547060Nerves fail to regenerate after injury and current medical practice is unable to manipulate effectively the process of nerve regeneration. This project will quantify how guidance cues, both individually and in combination, promote axon growth. The research results will provide an understanding of nerve development and of accurate and effective nerve regeneration. The goal of this proposal is to study the guidance of axons by multiple cues, including topography and specific molecules on surfaces, using microfabrication and microfluidics. The educational plan focuses on increasing oral communication skills, namely public speaking, of undergraduate and first year graduate students. The students in two classes that the principal investigator (PI) teaches will give seminars to non-scientific audiences. The PI will also run a workshop to help faculty teach communication skills in their classes.