CAREER: Axon Guidance by Multiple Cues

职业：多重线索的轴突引导

• 批准号: 0547060
• 负责人: Diane Hoffman-Kim
• 金额: $ 40万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547060&HistoricalAwards=false
• 关键词: CAREER; Axon; Guidance; Multiple; Cues

Hoffman-Kim0547060Nerves fail to regenerate after injury and current medical practice is unable to manipulate effectively the process of nerve regeneration. This project will quantify how guidance cues, both individually and in combination, promote axon growth. The research results will provide an understanding of nerve development and of accurate and effective nerve regeneration. The goal of this proposal is to study the guidance of axons by multiple cues, including topography and specific molecules on surfaces, using microfabrication and microfluidics. The educational plan focuses on increasing oral communication skills, namely public speaking, of undergraduate and first year graduate students. The students in two classes that the principal investigator (PI) teaches will give seminars to non-scientific audiences. The PI will also run a workshop to help faculty teach communication skills in their classes.

Hoffman-Kim 0547060神经损伤后不能再生，目前的医疗实践无法有效地操纵神经再生过程。这个项目将量化指导线索，无论是单独还是组合，促进轴突生长。研究结果将提供对神经发育和准确有效的神经再生的理解。 该提案的目标是通过多种线索研究轴突的指导，包括表面上的地形和特定分子，使用微加工和微流体。教育计划的重点是提高大学生和研究生一年级学生的口头交流技能，即公开演讲。主要研究者（PI）教授的两个班级的学生将为非科学观众举办研讨会。PI还将举办一个研讨会，帮助教师在课堂上教授沟通技巧。