CAREER: Shape-Adaptive Molecules: Understanding, Controlling, and Exploiting Molecular Motions

职业：形状自适应分子：理解、控制和利用分子运动

• 批准号: 0547251
• 负责人: Dongwhan Lee
• 金额: $ 54万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547251&HistoricalAwards=false
• 关键词: CAREER; Shape; Adaptive; Molecules; Understanding

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Dongwhan Lee at Indiana University to investigate a new class of shape-adaptive molecules as a general structural platform that can amplify and transmit conformational changes over a long distance. Using individually weak, but collectively strong, non-covalent interactions between symmetrically disposed bulky aromatics, this research offers an innovative solution to balance structural rigidity (to limit the number of competing conformations) and flexibility (to enable large-scale structural switching). The longer-term objective of this project is implementing viable mechanisms to transduce such mechanical signals to readable electrical signal outputs in molecular-level devices. By eliminating the requirement of direct electronic coupling between recognition events and signaling events, this research challenges and complements existing paradigms in molecular sensing. Construction and manipulation of such organized and interactive chemical systems require problem-solving skills crossing traditional disciplinary boundaries between inorganic, organic, analytical, and computational chemistry. The educational program supported by this award, Chemistry Beyond Molecules (CBM), will use materials chemistry as a versatile pedagogic tool for teaching undergraduate students. Through integration of lectures, laboratories, and summer projects that are designed to reinforce each other, CBM will "reintroduce" basic chemical concepts and encourage students to use organizing principles, not simple facts, to solve problems in interdisciplinary areas in chemistry. Active learning in multiple context, a key aspect of CBM, will help produce well-rounded problem solvers who can perform well in rapidly changing research environments that demand adaptive and transferrable skills.

这项由无机、生物无机和有机金属化学项目颁发的职业奖支持了印第安纳州大学Dongwhan Lee教授的工作，该工作旨在研究一类新的形状适应性分子，作为可以放大和传输的通用结构平台远距离构象变化。 利用对称布置的大体积芳烃之间的单独弱，但集体强的非共价相互作用，这项研究提供了一种创新的解决方案来平衡结构刚性（限制竞争构象的数量）和灵活性（实现大规模结构切换）。 该项目的长期目标是实施可行的机制，将这种机械信号转换为分子级设备中可读的电信号输出。 通过消除识别事件和信号事件之间的直接电子耦合的要求，这项研究挑战和补充现有的分子传感模式。 这种有组织的和互动的化学系统的建设和操作需要解决问题的技能跨越传统的学科之间的界限无机，有机，分析和计算化学。 由该奖项支持的教育计划，化学超越分子（CBM），将使用材料化学作为教学本科生的多功能教学工具。 通过整合讲座，实验室和旨在相互加强的暑期项目，CBM将“重新引入”基本化学概念，并鼓励学生使用组织原则，而不是简单的事实，来解决化学跨学科领域的问题。 主动学习在多种情况下，CBM的一个关键方面，将有助于产生全面的问题解决者谁可以在快速变化的研究环境，需要适应性和可转移的技能表现良好。