Epigenetic Control of a Maize Anthocyanin Regulatory Gene
玉米花青素调节基因的表观遗传控制
基本信息
- 批准号:0549447
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-01 至 2010-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The cells of every higher organism, whether plant or animal, face the problem of how to fit all their DNA into the nucleus while still allowing the genes to be accessible to the RNA synthesis machinery needed to turn those genes on at proper times in development. The universal solution to this dilemma is to wind the DNA around proteins to form a DNA-protein complex called chromatin. Genes in loosely wound chromatin are accessible to RNA synthesis machinery and are actively expressed, whereas genes in tightly wound chromatin are less accessible and are inactive. Winding is reversibly controlled by chemical alterations to the DNA or the proteins that make up the chromatin. Understanding how these chemical changes are regulated is the focus of this project. Experiments are aimed at analyzing the expression of the maize gene, Pl-Blotched, which controls the synthesis of purple pigments. Pl-Blotched plants have a variegated pattern of pigmentation that is associated with more tightly wound chromatin than usual and a unique pattern of chemical alteration to the Pl-Blotched DNA. To understand how these chromatin features are controlled, mutants with altered pigmentation have been isolated. To study how these mutants control the expression of Pl-Blotched, experiments will be conducted to determine what specific changes they induce in the DNA or proteins of Pl-Blotched chromatin. The results of these studies will contribute to our understanding of how gene expression can be controlled by chromatin in a diverse array of organisms that use chromatin-based mechanisms for regulating genes during growth and development. This project will be carried out by graduate and undergraduate students and will thus provide the students with strong training in genetics and genomics, with particular emphasis on teamwork and collaboration.
每一个高等有机体的细胞,无论是植物还是动物,都面临着一个问题,即如何将它们所有的DNA装入细胞核,同时仍然允许基因进入RNA合成机制,这是在发育的适当时间启动这些基因所需的。解决这一难题的普遍方法是将DNA缠绕在蛋白质周围,形成一种名为染色质的DNA-蛋白质复合体。松散缠绕的染色质中的基因可通过RNA合成机制获得并活跃表达,而紧密缠绕的染色质中的基因较难获得且不活跃。缠绕是由DNA或组成染色质的蛋白质的化学变化可逆控制的。了解这些化学变化是如何受到调控的是这个项目的重点。实验的目的是分析控制紫色色素合成的玉米基因Pl-Blotcher的表达。PL-Blotted植物具有五颜六色的色素沉着,这与比平时更紧密缠绕的染色质有关,以及对PL-Blotted DNA的独特化学改变模式。为了了解这些染色质特征是如何被控制的,我们已经分离出了色素改变的突变体。为了研究这些突变体如何控制Pl-Blotted的表达,将进行实验,以确定它们在Pl-Blotted染色质的DNA或蛋白质中诱导了哪些特定的变化。这些研究的结果将有助于我们理解染色质如何在各种生物中控制基因表达,这些生物使用基于染色质的机制来调节生长和发育过程中的基因。该项目将由研究生和本科生进行,因此将为学生提供强有力的遗传学和基因组学培训,特别强调团队合作和合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Candace Galen其他文献
Candace Galen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Candace Galen', 18)}}的其他基金
New, GK-12: ShowMe Nature from Elements to Ecosystems
新,GK-12:展示从元素到生态系统的自然
- 批准号:
1045322 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Friends in high places: Mycorrhizal associations in alpine communities
论文研究:高处之友:高山群落中的菌根协会
- 批准号:
0808000 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Standard Grant
50th Annual Maize Genetics Conference to be held in Washington, DC on February 27 - March 2, 2008
第 50 届年度玉米遗传学会议将于 2008 年 2 月 27 日至 3 月 2 日在华盛顿特区举行
- 批准号:
0813567 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Standard Grant
DISSERTATION RESEARCH: The impacts of partner abundance and niche breadth on benefits from mutualisms: Tracing outcomes from individuals to populations
论文研究:合作伙伴丰富度和利基宽度对互利共生收益的影响:追踪从个人到群体的结果
- 批准号:
0709833 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Standard Grant
UMEB: Training Ecologist Doctors for the 21st Century
UMEB:培养 21 世纪的生态学家医生
- 批准号:
0603049 - 财政年份:2006
- 资助金额:
-- - 项目类别:
Continuing Grant
Functional Genomics of Maize Chromatin
玉米染色质的功能基因组学
- 批准号:
0421619 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Cooperative Agreement
The Roles of Cheaters and Abiotic Stress in the Disruption of a Pollination Mutualism
作弊者和非生物胁迫在破坏授粉互利关系中的作用
- 批准号:
0316110 - 财政年份:2003
- 资助金额:
-- - 项目类别:
Standard Grant
ABR: Selection on Corolla Size By Flower Enemies--Impact on Male Fitness
ABR:花敌对花冠尺寸的选择--对男性健康的影响
- 批准号:
0087412 - 财政年份:2001
- 资助金额:
-- - 项目类别:
Standard Grant
Biotic and Abiotic Mechanisms for the Maintenance of Variation in Flower Form of an Alpine Wildflower
高山野花花形变化维持的生物和非生物机制
- 批准号:
9508741 - 财政年份:1995
- 资助金额:
-- - 项目类别:
Standard Grant
Dissertation Research: The Role of Nurse Effects in the Evolution of the Monocarpic Plant Life History
论文研究:护士效应在单果植物生命史进化中的作用
- 批准号:
9520553 - 财政年份:1995
- 资助金额:
-- - 项目类别:
Standard Grant
相似国自然基金
Cortical control of internal state in the insular cortex-claustrum region
- 批准号:
- 批准年份:2020
- 资助金额:25 万元
- 项目类别:
相似海外基金
RESEARCH-PGR: Transcriptional Control of the Maize Genome
研究-PGR:玉米基因组的转录控制
- 批准号:
1546781 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Standard Grant
An Integrated Phenomics Approach to Identifying the Genetic Basis for Maize Root Structure and Control of Plant Nutrient Relations
识别玉米根结构遗传基础和植物养分关系控制的综合表型组学方法
- 批准号:
1638507 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Continuing Grant
Do differentially regulated regions (DMRs) control imprinting of the maize fie1 and fie2 genes?
差异调节区 (DMR) 是否控制玉米 fie1 和 fie2 基因的印记?
- 批准号:
BB/E008585/1 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Research Grant
Control of Phyllotaxy in Maize by ABPHYL1, a Cytokinin Inducibe Response Regulator Homolog
ABPHYL1(一种细胞分裂素诱导反应调节剂同系物)对玉米叶序的控制
- 批准号:
0344738 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Continuing Grant
Genetic Control of Polar Nuclei Number in Maize Embryo Sacs
玉米胚囊极核数量的遗传控制
- 批准号:
0296074 - 财政年份:2001
- 资助金额:
-- - 项目类别:
Continuing Grant
Genetic Control of Polar Nuclei Number in Maize Embryo Sacs
玉米胚囊极核数量的遗传控制
- 批准号:
0080353 - 财政年份:2000
- 资助金额:
-- - 项目类别:
Continuing Grant
Chromatin-based Control of Gene Expression in Maize and Arabidopsis
基于染色质的玉米和拟南芥基因表达控制
- 批准号:
9975930 - 财政年份:1999
- 资助金额:
-- - 项目类别:
Cooperative Agreement
Gibberellin Biosynthesis & the Control of Growth in Maize
赤霉素生物合成
- 批准号:
8314338 - 财政年份:1984
- 资助金额:
-- - 项目类别:
Standard Grant
Genetic Control of Anthocyanin Biosynthesis in Maize
玉米花青素生物合成的遗传控制
- 批准号:
66B3992 - 财政年份:1966
- 资助金额:
-- - 项目类别:
Genetic Control of Carbohydrate Metabolism in Maize Endosperm
玉米胚乳碳水化合物代谢的遗传控制
- 批准号:
66B4523 - 财政年份:1966
- 资助金额:
-- - 项目类别: