Synthesis and function of heparin-containing block copolymers at interfaces

含肝素界面嵌段共聚物的合成及功能

• 批准号: 0602718
• 负责人: Joseph McGuire
• 金额: --
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0602718&HistoricalAwards=false
• 关键词: Synthesis; function; heparin; containing; block

0602718McGuireThis proposal describes a strategy to design, prepare, and characterize surfaces with covalently attached heparin to create thrombo-resistant surfaces. Heparin is among the most frequently anti-thrombotic drugs prescribed in hospitals, but long time administration results in side effects. In the proposed research, heparin will be tethered using surface grafted PEOs. PEO chains will be components of the tri-block copolymer PEO-PPO-PEO that will be covalently attached onto the solid surfaces at the position of the PPO segment. Low molecular weight heparin (LMWH) as opposed to unfractionated free heparin will be used. Biomaterials that are currently used as implants have surfaces that are not effectively thrombo-resistant, and heparin-coated biomaterials do not behave differently than unheparinized implants in vivo. The investigators hypothesize that the reason for this result is the inadequate control of surface attached heparin (spatial and structural character of heparin).

0602718 McGuire该提案描述了一种设计、制备和表征表面与共价连接的肝素以产生抗血栓表面的策略。肝素是医院最常用的抗血栓药物之一，但长期服用会产生副作用。在提议的研究中，肝素将使用表面接枝的PEO来栓系。PEO链将是三嵌段共聚物PEO-PPO-PEO的组分，其将在PPO链段的位置处共价连接到固体表面上。将使用低分子量肝素（LMWH），而不是普通游离肝素。目前用作植入物的生物材料的表面不能有效抗血栓，肝素涂层生物材料在体内的表现与未肝素化植入物没有区别。研究者假设该结果的原因是表面附着肝素的控制不足（肝素的空间和结构特征）。