Computational Modeling and Simulation of Aggregation of Red Blood Cells, and its Effect on Blood Flow in Microcirculation

红细胞聚集及其对微循环血流影响的计算模型和模拟

• 批准号: 0603035
• 负责人: Prosenjit Bagchi
• 金额: $ 20.21万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0603035&HistoricalAwards=false
• 关键词: Computational; Modeling; Simulation; Aggregation; Red

0603035BagchiThe main objective of the proposal is to study the rheology of blood in microcirculation. The major aims are (1) to develop advanced 3D computational models for red blood cells (RBC), and (2) investigate the RBC aggregation formation and its effect on blood flow patterns including white blood cell (WBC) margination. The simulation and modeling techniques developed will provide better understanding for high aggregation of blood cell phenomenon in various diseases (e.g. in sickle cell anemia, diabetes mellitus). The developed 3D models representing actual blood cells can impact different areas from microcirculations to biomechanics, and from biorheology to multiphase fluid flows. The educational and outreach components include graduate student training, course development, an undergraduate research program and involvement in summer research and Open Houses.

0603035巴奇该提案的主要目的是研究微循环中血液的流变学。主要目的是（1）开发用于红细胞（RBC）的高级3D计算模型，以及（2）研究RBC聚集形成及其对血流模式（包括白色血细胞（WBC）边缘化）的影响。 所开发的模拟和建模技术将提供对各种疾病（例如，镰状细胞性贫血、糖尿病）中的血细胞高度聚集现象的更好理解。开发的代表实际血细胞的3D模型可以影响从微循环到生物力学，从生物流变学到多相流体流动的不同领域。 教育和推广部分包括研究生培训，课程开发，本科研究计划和参与夏季研究和开放日。