Computational Modeling and Simulation of Aggregation of Red Blood Cells, and its Effect on Blood Flow in Microcirculation

本课题的主要目的是研究微循环血液流变学。主要目标是：(1)开发先进的红细胞（RBC）三维计算模型；(2)研究红细胞聚集形成及其对包括白细胞（WBC）边缘在内的血流模式的影响。所开发的模拟和建模技术将更好地理解各种疾病（如镰状细胞性贫血、糖尿病）中血细胞高度聚集的现象。开发的代表实际血细胞的3D模型可以影响从微循环到生物力学，从生物流变到多相流体流动的不同领域。教育和推广部分包括研究生培训，课程开发，本科生研究计划和参与夏季研究和开放日。

0603035BagchiThe main objective of the proposal is to study the rheology of blood in microcirculation. The major aims are (1) to develop advanced 3D computational models for red blood cells (RBC), and (2) investigate the RBC aggregation formation and its effect on blood flow patterns including white blood cell (WBC) margination. The simulation and modeling techniques developed will provide better understanding for high aggregation of blood cell phenomenon in various diseases (e.g. in sickle cell anemia, diabetes mellitus). The developed 3D models representing actual blood cells can impact different areas from microcirculations to biomechanics, and from biorheology to multiphase fluid flows. The educational and outreach components include graduate student training, course development, an undergraduate research program and involvement in summer research and Open Houses.