Network Hemodynamics: A Computational Study of Cellular Blood Flow and Particulate Transport in Microvascular Capillary Networks

网络血流动力学：微血管毛细血管网络中细胞血流和颗粒输送的计算研究

• 批准号: 1604308
• 负责人: Prosenjit Bagchi
• 金额: $ 38.35万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1604308&HistoricalAwards=false
• 关键词: Network; Hemodynamics; Computational; Study; Cellular

CBET - 1604308PI: Bagchi, ProsenjitThis award provides for support for numerical simulations and microfluidics-based experiments to study blood flow in small vessels and to examine the distribution of red blood cells among various branches of the vascular tree. Although this is a long-standing problem, the combination of advanced computations and experiments will provide new insights to help explain observations reported in the literature over decades. The numerical computations will examine the partitioning of red cells at vessel bifurcations where a vessel splits into two vessels and at locations where vessels recombine. The simulations will also examine time-dependent flow variations that are intrinsic to flow through vessel networks. Results from simulations will be compared with experiments of blood flow through microfluidic channels and networks of channels. The results of the project will be useful to scientists and engineers who work in areas such as tissue engineering, intravenous drug delivery, and in the design of blood-handling devices. The research will be incorporated into a summer course for high-school students titled "Computational Methods in Science and Engineering." Undergraduates, especially those from underrepresented groups, will be recruited to participate in the research.A three-dimensional, multiscale direct numerical simulation will be developed for deformable, poly-disperse blood cells flowing through networks of bifurcating, merging, and tortuous vessels. The model will include evolving cellular interfaces governed by hyper-viscoelastic constitutive laws and intricate stationary boundaries defined by the network architecture. The overall model will combine an immersed boundary method, a finite element method for interface deformation and a stochastic Monte-Carlo method for coarse-graining molecular interactions. The model will be validated by comparison with experiments of blood flow in networks of microfluidic channels. These tools will be used to examine the influence of network architecture on the distribution of blood cells, the network flow resistance, and the growth of self-sustained flow oscillations. The model will also be used to examine the influence of network architecture on the formation of blood clots and on deposition of drug-bearing particles. The results of this project will provide an organ-scale model of blood flow that retains cellular-scale dynamics.

CBET -1604308 PI：Bagchi，Prosenjit该奖项为数值模拟和基于微流体的实验提供支持，以研究小血管中的血流，并检查红细胞在血管树的各个分支中的分布。 虽然这是一个长期存在的问题，但先进的计算和实验的结合将提供新的见解，以帮助解释几十年来文献中报道的观测结果。 数值计算将检查红细胞在血管分叉处（其中一条血管分成两条血管）和血管重组处的分配。 模拟还将检查流经血管网络的固有的随时间变化的流量变化。 模拟结果将与通过微流体通道和通道网络的血液流动实验进行比较。 该项目的结果将有助于科学家和工程师在组织工程，静脉药物输送和血液处理设备的设计等领域工作。 这项研究将被纳入一个名为“科学与工程中的计算方法”的高中生暑期课程。“将招募大学生，特别是那些来自代表性不足的群体的大学生参与研究。将开发三维，多尺度的直接数值模拟，用于可变形，多分散的血细胞流过分叉，合并和曲折的血管网络。 该模型将包括不断发展的细胞界面超粘弹性本构关系和复杂的固定边界所定义的网络架构。 整个模型将结合联合收割机浸没边界法，有限元法的界面变形和随机蒙特-卡罗方法粗粒分子相互作用。 该模型将通过与微流体通道网络中血液流动的实验进行比较来验证。 这些工具将被用来检查网络结构对血细胞分布的影响，网络流动阻力，以及自我维持的流量振荡的增长。 该模型还将用于研究网络结构对血凝块形成和载药颗粒沉积的影响。 该项目的结果将提供一个器官尺度的血流模型，保留细胞尺度的动力学。