Understanding the role of octopamine in learning and memory formation

了解章鱼胺在学习和记忆形成中的作用

• 批准号: 175437060
• 负责人: Privatdozentin Dr. Dorothea Eisenhardt
• 金额: --
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/175437060?language=en
• 关键词: Understanding; role; octopamine; learning; memory

Octopamine (OA) is regarded as the transmitter of the reward pathway. However, the precise role of octopamine remains elusive. It is unclear if it mediates the reward prediction signal in classical conditioning and retrieval as it has been predicted by studies on the octopaminergic VUMmx1 neuron in the honeybee brain. In addition, it is unknown, whether octopamine plays an instructive role in appetitive learning as it has been suggested by several studies or if it plays a permissive role gating the CS-CR pathway.Given the number of potential octopamine receptors (OAR) in the honeybee brain and the number of brain regions octopaminergic neurons project to, it might well be, that octopamine fulfills several functions in the insect CNS that can only be identified by disentangling the role of different OARs and brain regions.Accordingly, we here want to study the role of different brain regions and different OARs in appetitive learning by utilizing the extinction learning paradigm that allows tostudy reward prediction in the honeybee.

章鱼胺被认为是奖赏通路的递质。然而，章鱼胺的确切作用仍然难以捉摸。目前尚不清楚它是否像对蜜蜂大脑中八胺能VUMmx1神经元的研究所预测的那样，在经典的条件反射和提取中介导了奖励预测信号。此外，尚不清楚章鱼胺是否如几项研究所暗示的那样在食欲学习中发挥指导作用，或者它是否在CS-CR通路上起到允许的作用。给定蜜蜂大脑中潜在的章鱼胺受体(OAR)的数量以及章鱼胺能神经元投射到的大脑区域的数量，章鱼胺很可能在昆虫中枢完成一些功能，这些功能只能通过解开不同的桨和脑区域的角色来识别。因此，我们希望通过利用灭绝学习范式来研究不同大脑区域和不同的桨在食欲学习中的作用。该范式允许研究蜜蜂的奖赏预测。