Electrostatically Driven Self-Assembly

静电驱动自组装

• 批准号: 0606282
• 负责人: Helmut Strey
• 金额: $ 33万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2010-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0606282&HistoricalAwards=false
• 关键词: Electrostatically; Driven; Self; Assembly

Non-technical: The project is aimed to investigate the role of electrostatic forces in the assembly of biological materials such as proteins, DNA condensation inside sperm heads, and formation of arterial plaque. The proposed research is strongly motivated by the richness of materials found in nature often displaying superior mechanical properties and functionalities. Under this project, biological molecules (peptides and proteins) will be combined with synthetic macromolecules (specific electrolytes and copolymers) to create novel functional hybrid materials with superior properties and performance. The results of this work impact the basic understanding of biological self-assembly processes and contribute to applications in the biotechnology and pharmaceutical industries. Our project is highly interdisciplinary and will train students and postdoctoral researchers in the increasingly complex interdisciplinary work in science, engineering and medicine. Our team members will acquire skills in state-of-the art microscopy, synchrotron X-ray scattering at national laboratories, and biochemical methods to prepare them for careers in academia, government and industry.Technical: The project will investigate electrostatically self-assembled materials. In particular, we will focus on complexes of charged objects (membranes, cylinders and spheres) with oppositely charged polyelectrolytes (PE) or tri-block copolymers (PE-neutral-PE). With this strategy, we expect to create functional hybrid materials from building blocks that are taken from biology (peptides and proteins) and synthetic polymer chemistry. By systematically varying the interaction strength and range between building blocks we will identify conditions for long-range order. The results of this work will not only impact the basic understanding of biological self-assembly processes, but also through extension to material science contribute to applications of self-assembled nanostructured materials in drug delivery, tissue engineering, bioseparation processes, biosensor materials, novel filter materials, as well as fuel cells. The interdisciplinary nature of the project will produce students and postdoctoral researchers that have a rigorous science background, are independent thinkers, and have an understanding of intellectual property and real world applications; all those aspects being highly valued by industry as well as academia.

非技术：该项目旨在研究静电力在生物材料（如蛋白质）组装中的作用，精子头部内的DNA凝结，以及动脉斑块的形成。在自然界中发现的材料的丰富性通常显示出优异的机械性能和功能，这强烈地推动了拟议的研究。在该项目下，生物分子（多肽和蛋白质）将与合成大分子（特定电解质和共聚物）结合，创造出具有优越性能的新型功能混合材料。这项工作的结果影响了对生物自组装过程的基本理解，并有助于在生物技术和制药行业的应用。我们的项目是高度跨学科的，将培养学生和博士后研究人员在科学、工程和医学领域日益复杂的跨学科工作。我们的团队成员将在国家实验室获得最先进的显微镜、同步加速器x射线散射和生化方法的技能，为他们在学术界、政府和工业界的职业生涯做好准备。技术：该项目将研究静电自组装材料。特别是，我们将关注带电物体（膜，圆柱体和球体）与相反带电的聚电解质（PE）或三嵌段共聚物（PE-中性PE）的配合物。通过这种策略，我们希望从生物学（肽和蛋白质）和合成聚合物化学中提取的构建块中创建功能混合材料。通过系统地改变构建块之间的相互作用强度和范围，我们将确定长期秩序的条件。这项工作的结果不仅将影响对生物自组装过程的基本理解，而且还将通过扩展到材料科学，有助于自组装纳米结构材料在药物输送，组织工程，生物分离过程，生物传感器材料，新型过滤材料以及燃料电池中的应用。该项目的跨学科性质将培养具有严谨科学背景、独立思考者、了解知识产权和现实世界应用的学生和博士后研究人员；所有这些方面都受到业界和学术界的高度重视。