Development and Applications of Electron Transfer Initiated Cyclization Reactions

电子转移引发环化反应的进展及应用

• 批准号: 0606757
• 负责人: Paul Floreancig
• 金额: $ 34万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0606757&HistoricalAwards=false
• 关键词: Development; Applications; Electron; Transfer; Initiated

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Paul Floreancig of the Chemistry Department at the University of Pittsburgh. This research will involve the development and applications of electron transfer initiated cyclization reactions. In this project the results from prior studies will be used to broaden the scope of these reactions in areas that impact small molecule and spatially directed synthesis. The applications of oxidative cleavage reactions will be expanded by designing new electroauxiliary groups based on enol ethers. The utility of these oxidative fragmentations for the synthesis of polycyclic ethers via cascade cyclizations will be examined. In addition, attempts will be made to tether photooxidants to oxidative cleavage moieties for potential use such as photodynamic therapies and photochemical surface modifications. In a broader sense, these projects exemplify the important role that physical organic chemistry can play in new reaction design. In this project, students will be exposed to research objectives in nanoscience. The emphasis on mechanistic analysis through first principles in this project imparts a significant benefit to students.

有了这个奖项，有机和大分子化学计划支持匹兹堡大学化学系的Paul Floreancig教授的工作。这项研究将涉及电子传递的开发和应用引发的环化反应。在该项目中，先前研究的结果将用于扩大影响小分子和空间定向合成的区域的范围。 氧化裂解反应的应用将通过基于烯醇醚设计新的电载体组来扩展。将检查这些氧化碎片对通过级联环化合成多环节的实用性。 此外，将尝试将光氧化剂链接到氧化裂解部分，以进行潜在使用，例如光动力疗法和光化学表面修饰。 从广义上讲，这些项目体现了物理有机化学在新反应设计中可以发挥的重要作用。在这个项目中，学生将暴露于纳米科学的研究目标。 通过该项目中的第一原理对机械分析的重视为学生带来了重大好处。