Development and Applications of Electron Transfer Initiated Cyclization Reactions

电子转移引发环化反应的进展及应用

• 批准号: 0606757
• 负责人: Paul Floreancig
• 金额: $ 34万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0606757&HistoricalAwards=false
• 关键词: Development; Applications; Electron; Transfer; Initiated

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Paul Floreancig of the Chemistry Department at the University of Pittsburgh. This research will involve the development and applications of electron transfer initiated cyclization reactions. In this project the results from prior studies will be used to broaden the scope of these reactions in areas that impact small molecule and spatially directed synthesis. The applications of oxidative cleavage reactions will be expanded by designing new electroauxiliary groups based on enol ethers. The utility of these oxidative fragmentations for the synthesis of polycyclic ethers via cascade cyclizations will be examined. In addition, attempts will be made to tether photooxidants to oxidative cleavage moieties for potential use such as photodynamic therapies and photochemical surface modifications. In a broader sense, these projects exemplify the important role that physical organic chemistry can play in new reaction design. In this project, students will be exposed to research objectives in nanoscience. The emphasis on mechanistic analysis through first principles in this project imparts a significant benefit to students.

有了这个奖项，有机和高分子化学计划支持匹兹堡大学化学系的Paul Floreancig教授的工作。本研究将涉及电子转移引发的环化反应的发展和应用。在本项目中，先前研究的结果将用于扩大这些反应在影响小分子和空间定向合成领域的范围。 通过设计新的烯醇醚类电辅助基团，将拓展氧化裂解反应的应用。这些氧化断裂的效用，通过级联环化多环醚的合成将被检查。 此外，将尝试将光氧化剂拴系到氧化裂解部分以用于潜在用途，例如光动力疗法和光化学表面修饰。 从更广泛的意义上说，这些项目证明了物理有机化学在新反应设计中的重要作用。在这个项目中，学生将接触到纳米科学的研究目标。 在这个项目中，通过第一原理强调机械分析给学生带来了显着的好处。