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DISSERTATION RESEARCH: A Measured Genotype Examination of the Effects of Dominance and Epistasis on Heritable Genetic Variation Across a Bottleneck

论文研究：显性和上位性对跨越瓶颈的可遗传遗传变异影响的测量基因型检查

基本信息

批准号：
0608352
负责人：
James Cheverud
金额：
$ 1.17万
依托单位：
Washington University School of Medicine
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608352&HistoricalAwards=false
关键词：
DISSERTATION RESEARCH Measured Genotype Examination

项目摘要

Changes in traits across generations depend on selection of heritable differences between individuals. Theory predicts that heritable differences between individuals will be reduced in small populations over time, limiting future adaptation, when gene-effects are independent of each other. However, when the effects of genes change depending on what other genes are present in the individual this loss of heritable variation may be limited. The investigators will examine changes in heritable variation over generations in a series of forty small experimental mouse populations derived from the cross of inbred strains. They had previously identified loci affecting body weight, fatpad weight, and tail length in these populations and found that the expected loss of heritable variance did not occur. The investigators will measure the genotypes at these loci and their contributions to heritable variance, identifying how context-dependent gene-effects prevent the loss of heritable variation in small populations.This research is important for understanding the genetic bases of species formation and adaptation in small populations. It has important implications for conservation of small populations and their ability to adapt to new circumstances. The context-dependent nature of gene-effects also has important consequences for our understanding of the genetic bases of complex diseases.

代际性状的变化取决于个体间遗传差异的选择。理论预测，当基因效应相互独立时，个体之间的遗传差异将随着时间的推移而减少，从而限制了未来的适应。然而，当基因的影响取决于个体中存在的其他基因时，这种可遗传变异的损失可能是有限的。研究人员将在一系列40个小型实验小鼠种群中检测遗传变异的变化，这些小鼠种群是由近交系杂交而来的。他们之前已经在这些人群中发现了影响体重、脂肪垫体重和尾巴长度的基因座，并发现预期的遗传变异损失没有发生。研究人员将测量这些位点上的基因型及其对遗传变异的贡献，确定环境依赖性基因效应如何在小群体中防止遗传变异的丧失。这项研究对了解小种群中物种形成和适应的遗传基础具有重要意义。这对保护小种群及其适应新环境的能力具有重要意义。基因效应的环境依赖性对我们理解复杂疾病的遗传基础也有重要影响。