NER: Integrated Magnetic and Chemical Assembly Techniques for Building Nanoparticle Arrays

NER：用于构建纳米粒子阵列的集成磁性和化学组装技术

• 批准号: 0608819
• 负责人: Benjamin Yellen
• 金额: --
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608819&HistoricalAwards=false
• 关键词: NER; Integrated; Magnetic; Chemical; Assembly

This Nanoscale Exploratory Research (NER) project aims to develop fluidic self-assembly strategies (via magnetic and chemical forces) to build arrays of metal nanoparticles on transparent substrates, serving as a low-cost, high-throughput solution for fabricating chip-based surface plasmon resonance (SPR) biosensors. The key concept employed in this work is that nonmagnetic materials, such as gold nanoparticles, can be manipulated inside a magnetizable fluid, such as ferrofluid (e.g. a fluid concentrated with magnetic nanoparticles). When an external field is applied to the fluid, the gold nanoparticles become negatively magnetized with respect to the surrounding medium, and as a result of dipole-dipole interactions, the gold nanoparticles will form well-ordered nanoparticle configurations with tunable periodicity. Once assembled into an array, chemical reactions initiated between the particle and substrate can embed the array structure on the surface even after rinsing of the ferrofluid. The intellectual merit lies in studying a relatively unexplored topic of manipulating nonmagnetic nanoparticles inside magnetic fluids. The major intellectual challenge is to develop computational methods for self-consistently calculating the magnetic field, resulting from magnetic nanoparticle concentration gradients and interactions with the substrate. The PI will encourage participation of undergraduate and graduate students in research as well as through the development of new courses in classical electricity and magnetism as defined in the context of the broader fields of self-assembly and nano-manipulation. Special emphasis will be placed on recruiting undergraduate students from a Historically Black College and University (HBCUs) or Historically Minority University (HMUs), and through the Duke University Pratt Fellows program.

该纳米级探索性研究(NER)项目旨在开发流体自组装策略(通过磁力和化学力)在透明衬底上构建金属纳米颗粒阵列，作为制造基于芯片的表面等离子体共振(SPR)生物传感器的低成本、高通量解决方案。这项工作中采用的关键概念是，非磁性材料，如金纳米颗粒，可以在可磁化的流体中进行操作，如磁性流体(例如，浓缩了磁性纳米颗粒的流体)。当外场作用于流体时，金纳米粒子相对于周围介质发生负磁化，由于偶极-偶极相互作用，金纳米粒子将形成有序的周期性可调的纳米粒子构型。一旦组装成阵列，即使在清洗磁流体之后，在颗粒和衬底之间引发的化学反应也可以将阵列结构嵌入到表面上。其学术价值在于研究了一个相对未被探索的课题，即在磁性液体中操纵非磁性纳米颗粒。主要的智力挑战是开发计算方法，以自洽地计算由磁性纳米颗粒浓度梯度和与衬底相互作用产生的磁场。该研究所将鼓励本科生和研究生参与研究，并根据自组装和纳米操纵的更广泛领域的定义，开发经典电学和磁学的新课程。将特别重视从历史上的黑人学院和大学(HBCU)或历史上的少数民族大学(HMU)以及通过杜克大学普拉特研究员计划招收本科生。