NIRT: Engineered Molecular Fluidics

摘要提案编号： 0609087标题： NIRT：工程分子流体PI： Sheiko，Sergei S. 位于教堂山的北卡罗来纳州大学这一提议是为了响应纳米科学与工程倡议，NSF 05-610，类别NIRT。 本计画将探索微加工流体学的新方向-分子流体学，其中一个人可以一次监测、探测和操纵一个分子的流动。将进行调查的行为上的流体单层驻留在固体基板上，可以操纵的电场和内在的手段，如与基板的相互作用。 所提出的方法是基于综合设计的流量和电场响应的分子，实验和理论研究的表面受限的大分子下流，和工程的流量驱动技术。将在从膜前的运动一直到膜内单个分子的运动的宽范围的长度尺度上监测流动。由于分子构象响应于流动，并可能响应于外部刺激，如电场，一个预期的分子装置，既可以探测的流动特性和积极影响的流动结构的发展。如果成功实施，电控表面将导致创造一系列新的材料和设备，使各向异性润湿，定向液体传输和各向异性摩擦学，甚至可能是自清洁或直接生长的活细胞的生物材料和植入物。实验结果将不断测试对理论预测和计算机模拟研究，并将指导其他功能性大分子的合成。关于更广泛的影响，拟议的研究将推进对表面限制聚合物链的构象和动力学的基本理解，并导致界面流及其与电场相互作用的新理论的发展。此外，在拟议的多学科研究领域的高度互动和高效的团队合作将确保最大的机会整合科学和教育的基础上，学生和博士后的跨学科培训，与6-12所学校的伙伴关系，并参与代表性不足的群体。合作教育计划涉及三个活动领域：（i）开发一门新的研究生课程和一个新的实验室模块，（ii）共同提供咨询和交换学生，使他们在聚合物化学、先进聚合物理论、可视化和微加工技术方面体验高度跨学科的教育，（iii）与本地中学定期交流，在大学举办介绍讲座及暑期研究计划。最重要的目标之一是将分子可视化从大学带到高中课堂，在那里看到分子的能力对于分子结构和化学反应的教学是非常宝贵的。

ABSTRACTProposal No.: 0609087Title: NIRT: Engineered Molecular FluidicsPI: Sheiko, Sergei S.Institution: University of North Carolina at Chapel HillThis proposal was received in response to Nanoscale Science and Engineering initiative, NSF 05-610, category NIRT. This project will explore a new direction in micro-fabricated fluidics molecular fluidics wherein one can monitor, probe, and manipulate flows one molecule at a time. Investigations will be performed on the behavior of fluid mono-layers residing on solid substrates that can be manipulated by both electric fields and intrinsic means such as the interaction with the substrate. The proposed approach is based on synthetic design of flow- and electric field-responsive molecules, experimental and theoretical studies of surface-confined macromolecules under flow, and the engineering of flow actuation techniques. The flow will be monitored over a broad range of length scales from the motion of the film front all the way down to the movements of individual molecules within the film. Since molecular conformation responds to flow and may respond to external stimuli such as electric fields, one anticipates the development of molecular devices that can both probe the flow properties and actively affect the flow structure. If successfully implemented, electrically controlled surfaces will lead to creation of a new range of materials and devices that enable anisotropic wetting, directional liquid transport, and anisotropic tribology, and may even be self-cleaning or direct the growth of live cells for biomaterials and implants. Experimental findings will be continuously tested against theoretical predictions and computer simulation studies, and will guide the synthesis of additional functional macromolecules. With respect to broader impacts, the proposed research will advance fundamental understanding of the conformation and dynamics of surface-confined polymer chains and lead to the development of new theories for interfacial flow and its interaction with electric fields. Furthermore, the highly interactive and efficient teamwork in the proposed multi-disciplinary research area will ensure maximum opportunity for integrating science and education based on the interdisciplinary training of student and postdocs, partnerships with 6-12 schools, and involvement of underrepresented groups. The collaborative education plan involves three areas of activity: (i) the development of a new graduate course and a new lab module, (ii) co-advising and an exchange of students that will experience a highly interdisciplinary education in polymer chemistry, advanced polymer theory, visualization and micro-fabrication techniques, (iii) and regular interactions with local high schools in form of introductory lectures and summer research programs at our universities. One of the most important goals is to bring molecular visualization from university to high-school classrooms where the ability to see molecules would be invaluable for the teaching of molecular structures and chemical reactions.