STTR Phase I: Miniature Biosensor Utilizing Nanomaterial Coatings

STTR 第一阶段：利用纳米材料涂层的微型生物传感器

• 批准号: 0611093
• 负责人: Michael Miller
• 金额: $ 9.98万
• 依托单位: PRIME RESEARCH LC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0611093&HistoricalAwards=false
• 关键词: STTR; Phase; Miniature; Biosensor; Utilizing

This Small Business Technology Transfer (STTR) program proposes combining photonic sensing, nanotechnology and biotechnology to demonstrate a new type of biosensor for laboratory use and rapid response to biological threats. The proposed device will be constructed from a new type of chemical-biological sensor which uses fiber optic grating sensor technology enhanced with unique new nanomaterial coatings. The combination of the new sensing method with the nanomaterial properties will result in a low-cost, rapid, highly sensitive and miniature device capable of battery operation and integration into a deployable unit. Detection has been demonstrated both for fluid-borne and air-borne targets, and the technique will detect bacteria, nerve agents, proteins and explosives. Expected detection limits for the final device range from 100 to 1000 times better than is currently possible using existing laboratory systems. Development of such a biosensor will require a concerted multidisciplinary effort in optical physics, biochemistry, and polymer and interfacial chemistry. If successful the proposed project will advance scientific knowledge in the following areas: (1) Advance the understanding of photonic sensing through the study of electromagnetic/optical field interactions in the photonic waveguide structures and in the overlying nanomaterial films, (2) Advance the development of nanomaterial applications through study of the covalent binding mechanisms between the affinity ligands and the ionic self-assembled multilayers (ISAM) film polymers, resulting in a general procedure for incorporating multiple classes of targets, (3) Advance the development of combinatorial evaluation techniques utilizing automated reasoners to reduce the requirement for high specificity sensing vectors, ultimately leading to intelligent sensing and reduced false alarm indications, and (4) Provide advanced educational opportunities through support of graduate and undergraduate students at Virginia Tech, specifically in the condensed matter and biotechnology areas.

这项小型企业技术转移计划建议将光子传感、纳米技术和生物技术相结合，以展示一种用于实验室和对生物威胁做出快速反应的新型生物传感器。提出的装置将由一种新型的化学-生物传感器构成，该传感器使用光纤光栅传感器技术，并通过独特的新型纳米材料涂层进行增强。将新的传感方法与纳米材料的特性相结合，将产生一种低成本、快速、高灵敏度和微型的设备，能够进行电池操作并集成到可展开的单元中。已经展示了对流体和空气目标的检测，该技术将检测细菌、神经毒剂、蛋白质和爆炸物。对最终设备的预期检测下限是目前使用现有实验室系统可能达到的100到1000倍。这种生物传感器的开发需要光学物理、生物化学、聚合物和界面化学等多学科的共同努力。如果成功，建议的项目将促进以下领域的科学知识：(1)通过研究光子波导结构和覆盖的纳米材料薄膜中的电磁/光场相互作用来促进对光子传感的理解，(2)通过研究亲和配体和离子自组装多层膜聚合物之间的共价结合机制来促进纳米材料应用的发展，从而产生结合多种靶标的一般程序，(3)利用自动推理来促进组合评估技术的发展，以减少对高特异性传感矢量的要求，最终导致智能传感和减少错误警报指示，以及(4)通过支持弗吉尼亚理工大学的研究生和本科生，特别是凝聚态和生物技术领域的研究生和本科生，提供高级教育机会。