Early developmental influences on neocortical organisation

对新皮质组织的早期发育影响

• 批准号: DE160101394
• 负责人: A/Prof Rodrigo Suarez
• 金额: $ 26.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160101394
• 关键词: Early; developmental; influences; neocortical; organisation

This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain region responsible for perception, motor planning and cognition. It expects to provide novel mechanistic and conceptual insights into the process of normal brain development and more general biological phenomena, such as development and evolution. It may also provide insights into several genetic and non-genetic causes of brain malformations.

该项目旨在确定先前发育阶段对大脑正确形成的影响。发展是一系列的转变，其中每个阶段都取决于前几个阶段的结果。该项目旨在研究早期感觉外围，早期出生的大脑回路和内在神经元相互作用如何影响大脑皮层的后续组织-一个负责感知，运动规划和认知的哺乳动物特有的大脑区域。它期望为正常大脑发育过程和更普遍的生物现象（如发育和进化）提供新的机制和概念见解。它还可以提供对大脑畸形的几个遗传和非遗传原因的见解。