How does timing affect mammalian brain development and evolution?

时间如何影响哺乳动物大脑的发育和进化？

• 批准号: DP200103093
• 负责人: A/Prof Rodrigo Suarez
• 金额: $ 31.53万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103093
• 关键词: How; does; timing; affect; mammalian

This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.

这个项目旨在通过研究有袋类动物和啮齿动物的发育来产生关于哺乳动物大脑回路多样性起源的基础知识。预期的结果是阐明基因表达、细胞分化和回路形成的时间、速度和序列的发展差异如何与哺乳动物大脑中关键进化创新的起源有关。了解形成复杂大脑特征的发育系统的动力学的意义包括建立新的进化理论发展范式，产生新的工具来研究和操纵活体中的脑基因表达，以及潜在地发现神经发育障碍的原因。