SBIR Phase I: Control System Development for Microelectromechanical Systems (MEMS) Segmented Deformable Mirrors

这个小企业创新研究（SBIR）第一阶段项目旨在开发用于自适应光学（AO）系统的基于分段变形镜（dm）的微机电系统（MEMS）的控制技术。这些AO系统校正了光学像差，这限制了几乎所有传统光学仪器的性能。MEMS DMs具有体积小、分辨率高、保真度高、成本低等特点，因此在生物成像领域具有很高的吸引力。对这些镜子的控制提出了一系列新的挑战，这些挑战尚未得到解决。AO系统已被证明能显著提高成像系统的性能，并已在体内证明细胞水平成像。使用AO可以非常高地增强图像对比度和有效分辨率，因此对细胞成像至关重要，从而可能导致早期疾病检测，更有效的药理学研究和基础生物学的进步。

This Small Business Innovation Research (SBIR) Phase I project aims to develop control techniques for microelectromechanical systems (MEMS) based segmented deformable mirrors (DMs) used in adaptive optical (AO) systems. These AO systems correct for optical aberrations, which limit the performance of virtually all conventional optical instruments. MEMS DMs are physically small, have high stoke and fidelity, and promise low cost, thus making them highly attractive in biological imaging. Control of these mirrors presents a new set of challenges, which have not yet been addressed.AO systems have been shown to yield dramatic improvement in the performance of imaging systems and have demonstrated cellular level imaging in vivo. The enhancements in image contrast and effective resolution by using AO can be very high and thus are pivotal enabling cellular imaging leading to potentially earlier disease detection, more effective pharmacological studies, and advances in basic biology.