SBIR Phase I: Control System Development for Microelectromechanical Systems (MEMS) Segmented Deformable Mirrors

该小型企业创新研究（SBIR）第一阶段项目旨在开发用于自适应光学（AO）系统的基于微机电系统（MEMS）的分段变形镜（DM）的控制技术。这些AO系统校正光学像差，这限制了几乎所有传统光学仪器的性能。MEMS DM物理上小，具有高斯托克和保真度，并且承诺低成本，因此使它们在生物成像中非常有吸引力。这些镜子的控制提出了一系列新的挑战，尚未得到解决。AO系统已被证明产生显着改善成像系统的性能，并已证明在体内细胞水平的成像。通过使用AO，图像对比度和有效分辨率的增强可以非常高，因此是关键的，能够使细胞成像导致潜在的早期疾病检测、更有效的药理学研究和基础生物学的进步。

This Small Business Innovation Research (SBIR) Phase I project aims to develop control techniques for microelectromechanical systems (MEMS) based segmented deformable mirrors (DMs) used in adaptive optical (AO) systems. These AO systems correct for optical aberrations, which limit the performance of virtually all conventional optical instruments. MEMS DMs are physically small, have high stoke and fidelity, and promise low cost, thus making them highly attractive in biological imaging. Control of these mirrors presents a new set of challenges, which have not yet been addressed.AO systems have been shown to yield dramatic improvement in the performance of imaging systems and have demonstrated cellular level imaging in vivo. The enhancements in image contrast and effective resolution by using AO can be very high and thus are pivotal enabling cellular imaging leading to potentially earlier disease detection, more effective pharmacological studies, and advances in basic biology.