Elucidation and Exploitation of Directed C-H Activation Reactions

通过这个新的奖项，有机和大分子化学项目支持了布兰代斯大学化学系于金泉教授的工作。本研究将重点研究催化和立体选择性碳氢化合物活化反应。合成有用的导向基团将被开发来辅助C-H裂解步骤。这些导向基团可以很容易地转换为对合成转换有用的官能团。新的定向基团将提供区域选择性和立体选择性的碳氢裂解过程将被设计。一个重要的目标是通过七元和八元环金属化过程选择性地激活远程碳氢键。为了在催化C-H活化反应中使用廉价和绿色的氧化剂，将开发温和和具有成本效益的催化体系来实现C-H功能化。该项目将采用广泛的物理有机和无机工具来寻求对这些催化反应的见解。一些本科生将参与这些研究，作为他们的论文工作和教育的一部分。预计简单羧酸和胺衍生物的区域选择性和立体选择性功能化将为合成提供有用的起始材料，并将对材料科学和药物合成等领域产生重大影响。

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Jin-Quan Yu of the Chemistry Department at Brandeis University. This research will focus on the investigation of catalytic and stereoselective C-H activation reactions. Synthetically useful directing groups will be developed to assist the C-H cleavage step. These directing groups will be readily converted to functional groups that are useful for synthetic transformations. Novel directing groups that will afford regioselectivity and stereoselectivity of the C-H cleavage process will be designed. A significant goal is to activate remote C-H bonds selectively via seven- and eight- membered cyclometallation processes. Mild and cost-effective catalytic systems to achieve C-H functionalization will be developed in order to allow the use of cheap and green oxidants in catalytic C-H activation reactions.This project will employ a wide range of physical organic and inorganic tools to seek insights into these catalytic reactions. A number of undergraduate students will be involved in these studies as part of their thesis work and education. It is expected that regioselective and stereoselective functionalizations of simple carboxylic acid and amine derivatives will provide useful starting materials for synthesis and should have a major impact on areas such as material science and pharmaceutical synthesis.