CAREER: Development of an Integrated Research and Education Program in Nanobiomechanical Analysis of Skeletal Fragility

0449188 akkus这一职业发展项目将为托莱多大学生物工程系的研究和教育整合奠定基础，以开发缓解骨骼脆弱性的治疗方法。该建议力求达到下列具体目标：(1)了解健康骨骼的分子和超分子水平的变形和断裂机制；(2)确定是否可以通过调节矿物纳米晶体的大小和几何形状来改善骨骼的力学功能；(3)将纳米生物力学的观点与现有的本科和研究生水平的生物力学课程相结合。(4)实现服务不足人群的本科生和高中生参与这些研究活动。

0449188AkkusThis CAREER development project will establish the foundation for integration of research and education at the Department of Bioengineering of the University of Toledo towards developing cures for alleviating skeletal fragility. The proposal seeks to attain the following specific objectives: (1) to understand the molecular and supramolecular level deformation and fracture mechanisms in healthy bone, (2) to determine whether bone's mechanical function can be improved by modulating the size and the geometry of mineral nanocrystals, (3) to integrate this nanobiomechanical perspective with the existing undergraduate- and graduate-level biomechanics curricula, and (4) to realize the participation of undergraduates and high-school students from under-served populations in these research activities.