RUI: Processing of Complex Sounds in the Auditory Midbrain
RUI:听觉中脑处理复杂声音
基本信息
- 批准号:0620560
- 负责人:
- 金额:$ 37.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-08-01 至 2009-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A fundamental function of the auditory system in humans is to process speech. Both speech sounds and social vocalizations of other animals are complex in that they are comprised of many frequency elements that vary over time. When these sounds are first encoded by the cochlea in the inner ear, they are broken down into their individual frequency elements and single neurons respond to individual frequency elements. However, to enable perception of the whole sound, neurons in the auditory system must recombine the individual frequency elements in theappropriate temporal order. In other words, individual neurons must integrate multiple frequency elements over time. The first site in the ascending auditory system where individual neurons integrate across frequency elements in complex sounds is the inferior colliculus (IC). The objective of this research is to determine the role of frequency and temporal integration in encoding complex sounds in the IC. In this project, responses of individual neurons in the IC to spectrally and temporally complex sounds, including natural vocalizations, will be obtained. The project focuses on characterizing neuronal responses that display nonlinear interactions to thecombination of two sounds with energy in different frequency bands. The project then examines how these "combination-sensitive" neurons encode natural sounds by presenting natural mouse vocalizations. Neural responses elicited by the entire vocalization, individual frequency elements and combinations of elements with different temporal relationships will be compared. The hypothesis tested is that neurons in the mouse IC show nonlinear frequency interactions to signals that contain biologically important frequency elements in the appropriate temporal order, and that these combination-sensitive interactions are a mechanism for encoding naturalvocalizations. The strength of this proposal is in utilizing naturally occurring, biologically relevant vocalizations in an awake mouse model to study neural mechanisms underlying the processing of complex sounds. Because mouse vocalizations have similar structures to the vowels of human speech, and similarities exist between the perception of multi-harmonic communication calls in mice and humans, this project will be an important step towards identifying the neural mechanisms of speech processing. The research activities in this project have an impact beyond the scientific findings. Dr. Portfors has established a diverse and committed record of educating students and the community. These activities include engaging minority students through research opportunities, undergraduate students through integration of research and teaching activities, and members of the local community through teacher training workshops, public lectures, and the local media. Dr. Portfors is regularly engaged in numerous activities outside the laboratory and classroom that have broad impact on the community. In a typical year, she and her students give 10-20 presentations to schools and community groups. This project will continue to foster interaction of undergraduate and graduate students in the laboratory and provide outreach to the community through presentations on auditory neuroscience.
人类听觉系统的一个基本功能是处理语音。其他动物的语音和社交发声都很复杂,因为它们由许多随时间变化的频率元素组成。当这些声音首先被内耳的耳蜗编码时,它们被分解成各自的频率元素,并且单个神经元对各个频率元素做出反应。然而,为了感知整个声音,听觉系统中的神经元必须以适当的时间顺序重新组合各个频率元素。换句话说,单个神经元必须随着时间的推移整合多个频率元素。在上行听觉系统中,单个神经元在复杂声音中跨频率元素进行整合的第一个部位是下丘 (IC)。本研究的目的是确定频率和时间整合在 IC 中编码复杂声音中的作用。在这个项目中,将获得 IC 中单个神经元对频谱和时间复杂声音(包括自然发声)的响应。该项目的重点是表征神经元响应,这些神经元响应对不同频段能量的两种声音的组合表现出非线性相互作用。然后,该项目研究了这些“组合敏感”神经元如何通过呈现自然的小鼠发声来编码自然声音。将比较由整个发声、单个频率元素以及具有不同时间关系的元素组合引起的神经反应。测试的假设是,小鼠 IC 中的神经元对包含适当时间顺序的生物学重要频率元素的信号表现出非线性频率相互作用,并且这些组合敏感的相互作用是编码自然发声的机制。该提案的优势在于利用清醒小鼠模型中自然发生的、生物学相关的发声来研究复杂声音处理背后的神经机制。由于小鼠发声与人类语音的元音结构相似,并且小鼠和人类对多谐波通信呼叫的感知之间存在相似性,因此该项目将是识别语音处理神经机制的重要一步。该项目的研究活动的影响超出了科学发现。 Portfors 博士在教育学生和社区方面建立了多元化和坚定的记录。这些活动包括通过研究机会吸引少数民族学生,通过研究和教学活动相结合吸引本科生,以及通过教师培训讲习班、公开讲座和当地媒体吸引当地社区成员。 Portfors 博士定期参加实验室和课堂之外的众多活动,对社区产生广泛影响。通常,她和她的学生每年都会向学校和社区团体进行 10 到 20 场演讲。该项目将继续促进实验室本科生和研究生的互动,并通过听觉神经科学的演示向社区提供推广服务。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Christine Portfors其他文献
Christine Portfors的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Christine Portfors', 18)}}的其他基金
RUI: Mechanisms of selectivity to behaviorally relevant sounds in the auditory midbrain
RUI:听觉中脑中行为相关声音的选择性机制
- 批准号:
1257768 - 财政年份:2013
- 资助金额:
$ 37.23万 - 项目类别:
Standard Grant
RUI: Neural Encoding of Behaviorally Relevant Sounds
RUI:行为相关声音的神经编码
- 批准号:
0920060 - 财政年份:2009
- 资助金额:
$ 37.23万 - 项目类别:
Standard Grant
相似国自然基金
Sirt1通过调控Gli3 processing维持SHH信号促进髓母细胞瘤的发展及机制研究
- 批准号:82373900
- 批准年份:2023
- 资助金额:48 万元
- 项目类别:面上项目
靶向Gli3 processing调控Shh信号通路的新型抑制剂治疗儿童髓母细胞瘤及相关作用机制研究
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
CAREER: Manufacturing USA: Deep Learning to Understand Fatigue Performance and Processing Relationship of Complex Parts by Additive Manufacturing for High-consequence Applications
职业:美国制造:通过深度学习了解复杂零件的疲劳性能和加工关系,通过增材制造实现高后果应用
- 批准号:
2239307 - 财政年份:2023
- 资助金额:
$ 37.23万 - 项目类别:
Standard Grant
Complex Big Data Processing Framework for Pervasice Traceability
用于普及可追溯性的复杂大数据处理框架
- 批准号:
23H03399 - 财政年份:2023
- 资助金额:
$ 37.23万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Understanding robust cellular information processing in complex environments and development of enabling single-cell analysis technologies
了解复杂环境中强大的细胞信息处理以及单细胞分析技术的开发
- 批准号:
10552335 - 财政年份:2023
- 资助金额:
$ 37.23万 - 项目类别:
Signal Processing and Information Extraction, from Data to Complex Models and Structures
信号处理和信息提取,从数据到复杂模型和结构
- 批准号:
RGPIN-2018-04079 - 财政年份:2022
- 资助金额:
$ 37.23万 - 项目类别:
Discovery Grants Program - Individual
Diagnostics of cold and highly reactive plasmas applied to complex materials and nanomaterials processing
适用于复杂材料和纳米材料加工的冷等离子体和高反应性等离子体的诊断
- 批准号:
RGPIN-2018-04550 - 财政年份:2022
- 资助金额:
$ 37.23万 - 项目类别:
Discovery Grants Program - Individual
DNA end processing by the Mre11/Rad50/Nbs1 complex in human cells
人类细胞中 Mre11/Rad50/Nbs1 复合物的 DNA 末端加工
- 批准号:
10415125 - 财政年份:2021
- 资助金额:
$ 37.23万 - 项目类别:
On-site processing of complex and cost-intensive capital investments (T09#)
现场处理复杂且成本密集的资本投资(T09
- 批准号:
448393981 - 财政年份:2021
- 资助金额:
$ 37.23万 - 项目类别:
CRC/Transregios (Transfer Project)
Diagnostics of cold and highly reactive plasmas applied to complex materials and nanomaterials processing
适用于复杂材料和纳米材料加工的冷等离子体和高反应性等离子体的诊断
- 批准号:
RGPIN-2018-04550 - 财政年份:2021
- 资助金额:
$ 37.23万 - 项目类别:
Discovery Grants Program - Individual
DNA end processing by the Mre11/Rad50/Nbs1 complex in human cells
人类细胞中 Mre11/Rad50/Nbs1 复合物的 DNA 末端加工
- 批准号:
10584584 - 财政年份:2021
- 资助金额:
$ 37.23万 - 项目类别:
Characterisation of a novel bacterial ribonucleoprotein complex analogous to eukaryotic processing (P) bodies in Escherichia coli
类似于大肠杆菌中的真核加工 (P) 体的新型细菌核糖核蛋白复合物的表征
- 批准号:
BB/V000284/1 - 财政年份:2021
- 资助金额:
$ 37.23万 - 项目类别:
Research Grant