Doctoral Dissertation Improvement Grant: Three-dimensional morphometrics and kinematics of the anthropoid wrist and the evolution of knuckle-walking

博士论文改进资助：类人猿手腕的三维形态测量和运动学以及指关节行走的进化

• 批准号: 0622515
• 负责人: Mary Marzke
• 金额: $ 0.6万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0622515&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Improvement; Grant; Three

Reconstructing the form of locomotion that preceded the evolution of human bipedality is a key goal of paleoanthropology. Knuckle-walking (a semi-terrestrial form of locomotion in which weight is borne on the backs of the middle hand phalanges) is a plausible candidate because it is practiced by the African apes, which are humans' closest living relatives. However, arguments for a knuckle-walking ancestor for the human evolutionary lineage rely on accurate interpretations of certain anatomical features in chimpanzees, gorillas, and early hominins (fossil species more closely related to humans than chimpanzees) as adaptations to knuckle-walking. The proposed project, to be conducted by Caley Orr under the direction of Dr. Mary Marzke and Dr. Mark Spencer at Arizona State University, will test the hypothesis of adaptation to knuckle-walking for such features using the comparative method. The interdisciplinary project will proceed by integrating innovative techniques from the fields of anthropology, computer science, and bioengineering. Wrist joint shape in anthropoid primates will be quantified from laser scan-derived three-dimensional digital models. In addition, the three-dimensional movements of the wrist bones will be analyzed using serial computed tomography scanning of primate cadavers to test specific hypotheses about the functional consequences of differences in joint shape between species. The knuckle-walking African apes will be compared with the digitigrade baboons, which also use a "vertical manus" form of locomotion, during which the palm is held vertically when placed onto the substrate. These species will be contrasted with several primates capable of using extended-wrist palmigrade hand positions during which the palm is typically placed onto the substrate. Joint mechanisms shared exclusively by the African apes and baboons will be supported as adaptations to maintaining vertical manus postures, and these features can be used to infer such hand postures in fossil species.The scientific merit of this study is that its novel integrative and quantitative approach facilitates the identification of features adapted to vertical manus postures. The appearance of these features in early hominins would support the hypothesis of a knuckle-walking ancestor. If a knuckle-walking phase in human evolution were to be demonstrated, it would limit adaptive explanations for the origins of bipedality to those consistent with a semi-terrestrial ancestor.Broader impacts of the project are its value for education of students at all levels and its clinical as well as academic applications. First, the 3D laser-scan models and developed analytical software will be shared via an online database to facilitate further research. The data and software will be useful for researchers and educators in anthropology, paleontology, anatomy, and biomedical fields such as orthopedics. Second, the project will provide a research experience for an undergraduate student who will assist with data processing and analysis. Finally, the project will provide an interdisciplinary training opportunity for Caley Orr in techniques from anthropology, anatomy, bioengineering, and computer visualization that will facilitate his future research and enhance his teaching at the university level.

重建人类两足行走进化之前的运动形式是古人类学的一个关键目标。 指关节行走（一种半陆地运动形式，重量由中指指骨的背面承担）是一个合理的候选者，因为非洲猿（人类现存的近亲）也有这种运动方式。 然而，关于人类进化谱系的指关节行走祖先的论点，依赖于对黑猩猩、大猩猩和早期人类（化石物种比黑猩猩与人类更接近）的某些解剖特征的准确解释，以适应指关节行走。这项计划将由亚利桑那州立大学的Caley Orr在玛丽马兹克博士和马克斯宾塞博士的指导下进行，该计划将使用比较方法来测试这些特征对关节行走的适应性假设。该跨学科项目将通过整合人类学，计算机科学和生物工程领域的创新技术进行。将从激光扫描衍生的三维数字模型中量化灵长类动物的腕关节形状。此外，将使用灵长类动物尸体的连续计算机断层扫描来分析腕骨的三维运动，以测试关于物种间关节形状差异的功能后果的特定假设。指关节行走的非洲猿类将与趾级狒狒进行比较，趾级狒狒也使用“垂直手”形式的运动，在此过程中，手掌放在基底上时保持垂直。这些物种将与几种灵长类动物能够使用延长腕掌移手的位置，在此期间，手掌通常放在基板上。非洲猿和狒狒特有的关节机制将被支持为保持垂直手姿势的适应性，这些特征可以用来推断化石物种中的手姿势，这项研究的科学价值在于其新颖的综合和定量方法有助于识别适应垂直手姿势的特征。这些特征在早期古人类中的出现支持了指关节行走祖先的假设。 如果要证明人类进化中的指关节行走阶段，它将限制对两足动物起源的适应性解释，使其与半陆地祖先相一致。该项目的更广泛影响是其对各级学生教育的价值，以及临床和学术应用。首先，3D激光扫描模型和开发的分析软件将通过在线数据库共享，以促进进一步的研究。这些数据和软件将对人类学、古生物学、解剖学和矫形外科等生物医学领域的研究人员和教育工作者有用。第二，该项目将提供一个本科生谁将协助数据处理和分析的研究经验。最后，该项目将为Caley Orr提供人类学，解剖学，生物工程和计算机可视化技术的跨学科培训机会，这将促进他未来的研究并提高他在大学的教学水平。