SGER: Electromechanical resonators as sensors for chemical and bio-molecules

（Goutam Kole）机电谐振器作为化学和生物分子的传感器。当前SGER的目标是使用机电谐振器来感测化学和生物分子。为了实现这一总体目标，将进行几个子任务：（i）研究悬臂梁谐振器对电荷和电势变化的灵敏度;（ii）研究悬臂梁中的参数谐振现象，以确定灵敏度的可能增强，特别是在粘性介质中;（iii）研究由于化学和生物分子在功能化表面上的吸附而引起的表面电势的变化;（iv）研究表面电势的变化。（iv）根据在一系列功能化表面上进行的测量，识别混合物中存在的每种化学或生物分子的特征。这些工作的智力价值包括增强了我们对悬臂梁谐振器中参数共振现象的理解，理解了由于吸附在特定功能化表面上的化学和生物分子引起的表面电势变化，并基于由化学和生物分子引起的n维电势变化来开发化学和生物分子的独特特征。更广泛的影响：该项目将影响单电子电荷和单光子探测的方法和仪器的开发。此外，该项目还将调查浸入液体介质的表面的潜在变化的测量结果，在为期一年的短期项目期间，将开展两项具体的教育和宣传活动：（i）我将让一名本科生参与传感器研究活动，他将与参与这项工作的研究生一起工作，及（ii）建立一个载有机电谐振传感器最新进展资料的网站。

(Goutam Kole)Electromechanical Resonators as Sensors for Chemical and Bio-molecules.The objective of the current SGER is to sense chemical and bio-molecules using electromechanical resonators. To attain this overall goal, several sub-tasks will be performed: (i) Investigation of the sensitivity of cantilever resonators to charge and potential changes; (ii) Investigation of the phenomenon of parametric resonance in cantilevers to determine possible enhancement in sensitivity, especially in viscous medium; (iii) Investigation of changes in surface potential due to adsorption of chemical and bio-molecules on functionalized surfaces; (iv) Identification of thesignature of each chemical or bio molecule present in a mixture, based onmeasurements conducted on an array of functionalized surfaces.Intellectual Merit: The intellectual merits of the proposed work includeenhancement of our understanding of the phenomenon of parametric resonance in cantilever resonators, understanding of surface potential changes due to adsorbed chemical and bio molecules on specific functionalized surface, and develop unique signatures of the chemical and bio-molecules based on n-dimensional potential changes caused by them. Broader Impacts: The project will impact the development of methodologies and apparatus for single electronic charge and perhaps single photon detection. In addition, it will investigate measurements of potential changes on surfaces immersed in liquid medium.During the short time duration of the project of one year, two specific education and outreach activities will be undertaken: (i) I will involve one undergraduate student in the sensor research activities, who will work with the graduate student involved in this work, and (ii) develop a website containing information on the latest advances on electromechanical resonator sensors.