SGER: Unsteady Fluid Mechanics of Nanoscale Vesicles of Lipid Bilayer, Fluid Membranes: Novel Drug Carriers

建议编号：CTS-0631280主要研究人员：Bobba，Kumar M.隶属：马萨诸塞州大学阿默斯特分校建议标题：SGER：纳米尺度脂类双层囊泡的非稳定流体力学，液膜：新型药物载体本建议已进行了内部审查。这项探索性研究的目的是研究纳米尺度的囊泡流体动力学行为。智力上的优点：囊泡的化学、动力学、结构和材料特性以及它们在细胞过程中所起的重要运输作用使它们成为细胞生物学的中心兴趣对象。这一建议的主要目的是(A)基于连续介质流体力学建立良好的囊泡模型；(B)对液膜中囊泡的不稳定性进行系统而严格的理论和计算研究。一个统一的多尺度框架将被开发，其中流体双层膜将被模拟为二维曲面上的Navier-Stokes流体，周围的水将被模拟为体积中的不可压缩的Stokesian流体。这项工作将为研究生和本科生提供研究机会，并将成果纳入教学活动。

ABSTRACTProposal Number: CTS-0631280Principal Investigator: Bobba, Kumar M.Affiliation: University of Massachussetts AmherstProposal Title: SGER: Unsteady Fluid Mechanics of Nanoscale Vesicles of Lipid Bilayer, Fluid Membranes: Novel Drug Carriers This proposal has undergone internal review. The aim of the proposed exploratory research is to investigate behavior of nanoscale vesicle fluid dynamics.Intellectual Merit:The chemical, dynamic, structural and material properties of vesicles and the important transport role that they play in the cellular processes make them an object of central interest in cell biology. The primary objective of this proposal is (a) to develop good models for vesicles based on continuum fluid mechanics and (b) to do a systematic and rigorous theoretical and computational study of instabilities in vesicles of fluid membranes. A unified multiscale framework will be developed, wherein the fluid bilayer membrane will be modeled as a Navier-Stokes fluid on a two-dimensional curved surface and the surrounding water will be modeled as an incompressible, Stokesian fluid in a volume.Broader Impacts:Apart from their intrinsic scientific interest, vesicles can also be used to build biomachines for controlled drug delivery, gene therapy, etc. and hence are of technological and practical importance. The work will provide graduate and undergraduate research opportunities, and outcomes will be incorporated into teaching activities.