CRIF: MU Purchase of an LC/Ion Trap Mass Spectrometer

南密西西比大学化学系将从化学研究仪器和设施：多用户（CRIF:MU）项目中获得一台液相色谱（LC）离子阱质谱仪。该仪器将用于支持结构、反应和分析研究的各种研究项目：1)气相肽和蛋白质消化；2)顺磁性过渡金属配合物在环氧化和羟基化反应中用作不对称催化剂；3)生物活性肽成熟的酶学；4)羧基体组装途径及壳蛋白之间的排列和相互作用；5)类核蛋白和可能影响其与ctDNA相互作用的潜在翻译后修饰；6) rna催化剂。质谱分析用于化学和生化研究，通过测量所研究化合物的质量来鉴定分子及其结构。液相色谱法在质谱分析之前，通过将混合物分离和纯化成更简单的成分。质谱分析培训是化学、生物化学和材料科学专业学生专业发展不可或缺的一部分。本仪器将用于本科生实验教学和本科生、研究生的研究项目。

The Chemistry Department at Southern Mississippi University will acquire a liquid chromatography (LC) ion trap mass spectrometer with this award from the Chemistry Research Instrumentation and Facilities: Multi User (CRIF:MU) program. The instrument will be employed in a wide variety of research projects supporting structural, reaction, and analytical studies of: 1) gas phase peptide and protein digestion; 2) paramagnetic transition metal complexes used as asymmetric catalysts in epoxidation and hydroxylation reactions; 3) enzymology of bioctive peptide maturation; 4) the carboxysome assembly pathway and the arrangement and interactions between shell proteins; 5) nucleoid proteins and potential posttranslational modifications that might affect their interaction with ctDNA; and 6) RNA-catalysts.Mass spectrometry analysis is used in chemical and biochemical research to identify molecules and their structures by measuring the mass of the compounds under study. Liquid chromatography precedes the mass spectral analysis by separating and purifying a mixture of compounds into its simpler components. Training in mass spectrometry analysis is integral to the professional development of chemistry, biochemistry and materials science students. This instrument will be used in undergraduate laboratory course instruction and in the research projects of undergraduates and graduate students.