CRIF: MU Purchase of an LC/Ion Trap Mass Spectrometer

南密西西比大学的化学系将从化学研究仪器和设施：多用户（CRIF：MU）计划中获得一台液相色谱（LC）离子阱质谱仪。 该仪器将用于支持以下研究项目的结构、反应和分析研究：1）气相肽和蛋白质消化; 2）用作环氧化和羟基化反应中的不对称催化剂的顺磁性过渡金属络合物; 3）生物活性肽成熟的酶学; 4）羧基体组装途径和壳蛋白之间的排列和相互作用; 5）类核蛋白和可能影响其与ctDNA相互作用的潜在翻译后修饰;和6）RNA催化剂。质谱分析用于化学和生物化学研究，通过测量所研究化合物的质量来鉴定分子及其结构。液相色谱法先于质谱分析，将化合物的混合物分离和纯化成其更简单的组分。 质谱分析培训是化学，生物化学和材料科学专业学生专业发展的组成部分。 该仪器将用于本科实验课程教学和本科生和研究生的研究项目。

The Chemistry Department at Southern Mississippi University will acquire a liquid chromatography (LC) ion trap mass spectrometer with this award from the Chemistry Research Instrumentation and Facilities: Multi User (CRIF:MU) program. The instrument will be employed in a wide variety of research projects supporting structural, reaction, and analytical studies of: 1) gas phase peptide and protein digestion; 2) paramagnetic transition metal complexes used as asymmetric catalysts in epoxidation and hydroxylation reactions; 3) enzymology of bioctive peptide maturation; 4) the carboxysome assembly pathway and the arrangement and interactions between shell proteins; 5) nucleoid proteins and potential posttranslational modifications that might affect their interaction with ctDNA; and 6) RNA-catalysts.Mass spectrometry analysis is used in chemical and biochemical research to identify molecules and their structures by measuring the mass of the compounds under study. Liquid chromatography precedes the mass spectral analysis by separating and purifying a mixture of compounds into its simpler components. Training in mass spectrometry analysis is integral to the professional development of chemistry, biochemistry and materials science students. This instrument will be used in undergraduate laboratory course instruction and in the research projects of undergraduates and graduate students.