Linking Evolution to Genomics Using Phenotype Ontologies
使用表型本体将进化与基因组学联系起来
基本信息
- 批准号:0641025
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-06-01 至 2011-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The University of South Dakota Main Campus is awarded a grant to develop tools to integrate evolutionary and model organism phenotype data using ontologies in order to address questions about the genetic and developmental regulation of evolutionary morphological transitions. The project will develop and apply ontologies for taxa and phenotypes in a large clade of fishes (the Ostariophysi) and to develop a suite of database and web-interface tools that will enable researchers to investigate relationships between evolutionary phenotypes and those seen in genetically characterized developmental mutants of zebrafish (a species within Ostariophysi). Combining the wealth of genomic data on the numerous phenotypic mutants for zebrafish, with the span of corresponding anatomical diversity in ostariophysan species will allow researchers to discover previously unrealized connections between evolutionary change, genes, and the developmental processes in which these genes play a role. The team will demonstrate the feasibility of the approach by implementing a select number of use-case queries as a proof-of-concept. The queries will be implemented via a web-based user interface for searching and analyzing the data content. The research will be carried out in collaboration with the National Evolutionary Synthesis Center at the University of North Carolina.
南达科他州主校区的大学被授予赠款开发工具,以整合进化和模型生物表型数据使用本体,以解决有关进化形态转变的遗传和发育调控的问题。该项目将开发和应用一个大型鱼类分支(Ostariophysi)的分类群和表型的本体论,并开发一套数据库和网络界面工具,使研究人员能够调查进化表型与斑马鱼(Ostariophysi内的一个物种)遗传特征发育突变体之间的关系。结合丰富的斑马鱼表型突变体的基因组数据,与ostarioprotian物种相应的解剖学多样性的跨度将使研究人员能够发现以前未实现的进化变化,基因和这些基因发挥作用的发育过程之间的联系。该团队将通过实现选定数量的用例查询作为概念验证来证明该方法的可行性。查询将通过基于网络的用户界面进行,用于搜索和分析数据内容。这项研究将与北卡罗来纳州大学的国家进化合成中心合作进行。
项目成果
期刊论文数量(0)
专著数量(0)
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专利数量(0)
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Paula Mabee其他文献
Open Science principles for accelerating trait-based science across the Tree of Life
用于加速整个生命之树基于性状的科学的开放科学原则
- DOI:
10.1038/s41559-020-1109-6 - 发表时间:
2020-02-17 - 期刊:
- 影响因子:14.500
- 作者:
Rachael V. Gallagher;Daniel S. Falster;Brian S. Maitner;Roberto Salguero-Gómez;Vigdis Vandvik;William D. Pearse;Florian D. Schneider;Jens Kattge;Jorrit H. Poelen;Joshua S. Madin;Markus J. Ankenbrand;Caterina Penone;Xiao Feng;Vanessa M. Adams;John Alroy;Samuel C. Andrew;Meghan A. Balk;Lucie M. Bland;Brad L. Boyle;Catherine H. Bravo-Avila;Ian Brennan;Alexandra J. R. Carthey;Renee Catullo;Brittany R. Cavazos;Dalia A. Conde;Steven L. Chown;Belen Fadrique;Heloise Gibb;Aud H. Halbritter;Jennifer Hammock;J. Aaron Hogan;Hamish Holewa;Michael Hope;Colleen M. Iversen;Malte Jochum;Michael Kearney;Alexander Keller;Paula Mabee;Peter Manning;Luke McCormack;Sean T. Michaletz;Daniel S. Park;Timothy M. Perez;Silvia Pineda-Munoz;Courtenay A. Ray;Maurizio Rossetto;Hervé Sauquet;Benjamin Sparrow;Marko J. Spasojevic;Richard J. Telford;Joseph A. Tobias;Cyrille Violle;Ramona Walls;Katherine C. B. Weiss;Mark Westoby;Ian J. Wright;Brian J. Enquist - 通讯作者:
Brian J. Enquist
Phenotype Ontology Research Coordination Network meeting report: creating a community network for comparing and leveraging phenotype-genotype knowledge across species
- DOI:
10.4056/sigs.2926219 - 发表时间:
2012-07-20 - 期刊:
- 影响因子:5.400
- 作者:
Paula Mabee;Andrew Deans;Eva Huala;Suzanna E. Lewis - 通讯作者:
Suzanna E. Lewis
Paula Mabee的其他文献
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{{ truncateString('Paula Mabee', 18)}}的其他基金
NEON Operations and Maintenance: Evolving from a Strong Foundation
NEON 运营和维护:从强大的基础发展而来
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2217817 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Cooperative Agreement
National Ecological Observatory Network Governing Cooperative Agreement
国家生态观测站网络治理合作协议
- 批准号:
2346114 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Cooperative Agreement
Collaborative Research: Biology-guided neural networks for discovering phenotypic traits
合作研究:生物学引导的神经网络发现表型特征
- 批准号:
2022042 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Continuing Grant
Collaborative Research: Biology-guided neural networks for discovering phenotypic traits
合作研究:生物学引导的神经网络发现表型特征
- 批准号:
1940340 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Continuing Grant
National Ecological Observatory Network: Operations Activities
国家生态观测站网络:运行活动
- 批准号:
1724433 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Cooperative Agreement
National Ecological Observatory Network
国家生态观测网
- 批准号:
1638694 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Cooperative Agreement
National Ecological Observatory Network: Operations Activities
国家生态观测站网络:运行活动
- 批准号:
1638696 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Cooperative Agreement
Collaborative research: ABI Development: Ontology-enabled reasoning across phenotypes from evolution and model organisms
合作研究:ABI 开发:跨进化和模式生物表型的本体推理
- 批准号:
1062542 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Continuing Grant
AToL: Collaborative Research: Systematics of Cypriniformes, Earth's Most Diverse Clade of Freshwater Fishes
AToL:合作研究:鲤形目(地球上最多样化的淡水鱼分支)的系统学
- 批准号:
0431290 - 财政年份:2004
- 资助金额:
-- - 项目类别:
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A Comparative Experimental Study of Cranial Development in Teleosts
硬骨鱼颅骨发育的比较实验研究
- 批准号:
9896253 - 财政年份:1998
- 资助金额:
-- - 项目类别:
Continuing Grant
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