A Comparative Experimental Study of Cranial Development in Teleosts

9408287马比拟议研究的中心目标是了解鱼类头骨的发育。为了实现这一目标，PI将使用实验发展技术获取数据，并使用系统发育系统学方法合成这些数据。PI将使用现代血统追踪方法，结合数字成像技术和视频显微镜来评估胎盘和神经脊对皮肤颅骨的相对胚胎学贡献。这一点意义重大，因为没有关于鱼类的信息就不能对脊椎动物的骨骼发育历史做出任何假设，而且到目前为止还没有关于鱼类的实验数据。这项研究将提供这些数据。

9408287 Mabee The central goal of the proposed research is to understand the development of the cranial skeleton in fishes. Toward this goal, the PI will acquire data using experimental developmental techniques and synthesize these data using the methods of phylogenetic systematics. The PI will use modern lineage tracing methods, with digital imaging techniques and video microscopy to assess the relative embryological contribution of placode and neural crest to dermal cranial bones. This is significant because no hypotheses on the history of skeletal development in vertebrates can be made without information on fishes, and so far no experimental data on fishes are available. This study will provide these data.